PMID- 24843699
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140520
LR  - 20211021
IS  - 2040-1116 (Print)
IS  - 2040-1124 (Electronic)
IS  - 2040-1116 (Linking)
VI  - 4
IP  - 5
DP  - 2013 Sep 13
TI  - Serum arylhydrocarbon receptor transactivating activity is elevated in type 2 
      diabetic patients with diabetic nephropathy.
PG  - 483-91
LID - 10.1111/jdi.12081 [doi]
AB  - AIMS/INTRODUCTION: Evidence is emerging that exposure to persistent organic 
      pollutants (POPs) is a risk factor for obesity-related diseases and for diabetes 
      mellitus (DM). We found that POPs could be measured by a cell-based 
      arylhydrocarbon receptor (AhR)-dependent reporter assay. We tested if serum AhR 
      transactivating (AHRT) activities are a risk factor for diabetic nephropathy in 
      people with type 2 diabetes. MATERIALS AND METHODS: We enrolled diabetic patients 
      with normoalbuminuria (n = 36), microalbuminuria (n = 29), macroalbuminuria 
      (n = 8) and end-stage renal disease (n = 31). Sera were tested for their AHRT 
      activities, which were standardized by an AhR ligand, 
      2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and expressed as TCDD equivalents 
      (TCDDeq pmol/L). RESULTS: Mean serum AHRT activities were higher in patients with 
      microalbuminuria (40.1 +/- 7.1 pmol/L), macroalbuminuria (37.4 +/- 5.5 pmol/L) and 
      end-stage renal disease (59.1 +/- 20.0 pmol/L) than in subjects with 
      normoalbuminuria (12.7 +/- 5.4 pmol/L; P < 0.05 for all comparisons). Serum AhR 
      ligands showed a correlation with estimated glomerular filtration rate (eGFR; 
      r = -0.663, P < 0.001), serum creatinine level (r = 0.635, P < 0.001), systolic 
      blood pressure (r = 0.223, P = 0.026), glycated hemoglobim (r = 0.339, P < 0.001) 
      and diabetic duration (r = 0.394, P < 0.001). In a multiple regression analysis, 
      diabetic nephropathy was found to be an independent risk factor for higher AHRT 
      activity after controlling for the confounding factors. CONCLUSIONS: The present 
      findings suggest serum AHRT activity, thus serum AhR ligands, is a risk factor 
      for diabetic nephropathy. Further studies are required to clarify if an 
      accumulation of POPs in the body is causally related to diabetic nephropathy.
FAU - Kim, Jin Taek
AU  - Kim JT
AD  - Department of Internal Medicine College of Medicine Eulji University Seoul Korea.
FAU - Kim, Sang Soo
AU  - Kim SS
AD  - Eulji Medi-Bio Research Institute Seoul Korea.
FAU - Jun, Dae Won
AU  - Jun DW
AD  - Department of Internal Medicine College of Medicine Hanyang University Seoul 
      Korea.
FAU - Hwang, Young Hwan
AU  - Hwang YH
AD  - Department of Internal Medicine College of Medicine Eulji University Seoul Korea.
FAU - Park, Wook-Ha
AU  - Park WH
AD  - Department of Physiology College of Medicine Kyung Hee University Seoul Korea.
FAU - Pak, Youngmi Kim
AU  - Pak YK
AD  - Department of Physiology College of Medicine Kyung Hee University Seoul Korea.
FAU - Lee, Hong Kyu
AU  - Lee HK
AD  - Department of Internal Medicine College of Medicine Eulji University Seoul Korea.
LA  - eng
PT  - Journal Article
DEP - 20130422
PL  - Japan
TA  - J Diabetes Investig
JT  - Journal of diabetes investigation
JID - 101520702
PMC - PMC4025111
OTO - NOTNLM
OT  - Aryl hydrocarbon receptor ligands
OT  - Diabetic nephropathy
OT  - Persistent organic pollutants
EDAT- 2014/05/21 06:00
MHDA- 2014/05/21 06:01
PMCR- 2013/09/13
CRDT- 2014/05/21 06:00
PHST- 2012/08/24 00:00 [received]
PHST- 2013/02/20 00:00 [revised]
PHST- 2013/02/22 00:00 [accepted]
PHST- 2014/05/21 06:00 [entrez]
PHST- 2014/05/21 06:00 [pubmed]
PHST- 2014/05/21 06:01 [medline]
PHST- 2013/09/13 00:00 [pmc-release]
AID - JDI12081 [pii]
AID - 10.1111/jdi.12081 [doi]
PST - ppublish
SO  - J Diabetes Investig. 2013 Sep 13;4(5):483-91. doi: 10.1111/jdi.12081. Epub 2013 
      Apr 22.