PMID- 24843803
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140520
LR  - 20211021
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 6
IP  - 3
DP  - 2014 May
TI  - The Prevalence of Serum Specific IgE to Superantigens in Asthma and Allergic 
      Rhinitis Patients.
PG  - 263-6
LID - 10.4168/aair.2014.6.3.263 [doi]
AB  - Staphylococcus aureus is the most common bacterium present in upper respiratory 
      tract, and the toxins it produced are involved in allergic inflammation 
      pathogenesis. In this study, we investigated the clinical significance of IgE in 
      association with staphylococcal superantigens in allergic asthma with rhinitis 
      (BAwAR) and allergic rhinitis alone (AR). We recruited 100 patients with BAwAR 
      (group I), 100 patients with AR (group II), and 88 healthy controls (group III). 
      Patients were clinically diagnosed by physicians, and were sensitized to house 
      dust mites. Specific IgE antibodies to staphylococcal superantigen A (SEA), B 
      (SEB), and toxic shock syndrome toxin-1 (TSST-1) were measured using the 
      ImmunoCAP system. Other clinical parameters were retrospectively analyzed. All 
      specific IgE antibodies to SEA, SEB, and TSST-1 were detected most frequently in 
      group I (22%, 21%, and 27%), followed by group II (11%, 14%, and 21%) and group 
      III (4.5%, 3.4%, and 2.3%). Absolute values of serum specific IgE to SEA, SEB, 
      and TSST-1 were also significantly higher in group I (0.300+/-1.533 kU/L, 
      0.663+/-2.933 kU/L, and 0.581+/-1.931 kU/L) and group II (0.502+/-2.011 kU/L, 
      0.695+/-3.337 kU/L, and 1.067+/-4.688 kU/L) compared to those in group III 
      (0.03+/-0.133 kU/L, 0.03+/-0.14 kU/L, and 0.028+/-0.112 kU/L). The prevalence of serum 
      specific IgE to SEA was significantly higher in group I compared to group II 
      (P=0.025). Blood eosinophil counts were significantly higher in patients with 
      specific IgE to SEA or SEB, and higher serum levels of specific IgE to house dust 
      mites were noted in patients with specific IgE to TSST-1. In conclusion, the 
      present study suggested that IgE responses to staphylococcal superantigens are 
      prevalent in the sera of both BAwAR and AR patients. This may contribute to an 
      augmented IgE response to indoor allergens and eosinophilic inflammation.
FAU - Liu, Jing Nan
AU  - Liu JN
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Shin, Yoo Seob
AU  - Shin YS
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Yoo, Hye-Soo
AU  - Yoo HS
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Nam, Young Hee
AU  - Nam YH
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Jin, Hyun Jung
AU  - Jin HJ
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Ye, Young-Min
AU  - Ye YM
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Nahm, Dong-Ho
AU  - Nahm DH
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Park, Hae-Sim
AU  - Park HS
AUID- ORCID: 0000-0003-2614-0303
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140110
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC4021246
OTO - NOTNLM
OT  - Superantigen
OT  - allergic rhinitis
OT  - bronchial asthma
OT  - specific IgE
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2014/05/21 06:00
MHDA- 2014/05/21 06:01
PMCR- 2014/05/01
CRDT- 2014/05/21 06:00
PHST- 2012/10/30 00:00 [received]
PHST- 2013/06/26 00:00 [revised]
PHST- 2013/07/19 00:00 [accepted]
PHST- 2014/05/21 06:00 [entrez]
PHST- 2014/05/21 06:00 [pubmed]
PHST- 2014/05/21 06:01 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - 10.4168/aair.2014.6.3.263 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2014 May;6(3):263-6. doi: 10.4168/aair.2014.6.3.263. 
      Epub 2014 Jan 10.