PMID- 24844973
OWN - NLM
STAT- MEDLINE
DCOM- 20141014
LR  - 20220321
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 158
IP  - 2
DP  - 2014 Aug
TI  - Comparison of exudative age-related macular degeneration subtypes in Japanese and 
      French Patients: multicenter diagnosis with multimodal imaging.
PG  - 309-318.e2
LID - S0002-9394(14)00238-4 [pii]
LID - 10.1016/j.ajo.2014.05.004 [doi]
AB  - PURPOSE: To compare and analyze differences and similarities between Japanese and 
      French patients in subtype diagnosis of exudative age-related macular 
      degeneration (AMD) as determined by fundus photography (FP) and fluorescein 
      angiography (FA), and a multimodal imaging involving FP, FA, indocyanine green 
      angiography (ICGA), and optical coherence tomography (OCT). DESIGN: Retrospective 
      chart review. METHODS: We determined the subtype diagnosis for 99 consecutive 
      Japanese eyes and 94 consecutive French eyes with exudative AMD. The first-step 
      diagnosis was made using FP and FA, while the second-step diagnosis was made 
      using FP, FA/ICGA, and OCT. The diagnoses made by Japanese and French physicians 
      were compared, and when the diagnoses differed, a third institute was consulted 
      to arrive at a final consensus and diagnosis. RESULTS: The first-step diagnosis 
      showed 20%-30% disagreement against the final diagnosis, but the second-step 
      diagnosis showed only 10% disagreement. Polypoidal choroidal vasculopathy (PCV) 
      was observed more in Japanese patients (48%) than in French (9%), and the rate of 
      PCV with type 1 or 2 choroidal neovascularization (CNV) was extremely low: 3% in 
      Japanese and 0% in French. Type 1 CNV was found significantly more in French 
      cases (53.3% vs 35.1%, P=.018), while the rate of eyes with type 2 CNV only or 
      chorioretinal anastomosis was similar between populations. CONCLUSIONS: 
      Multimodality imaging significantly improved the sub-classification of AMD. There 
      were significant differences between the 2 series in the proportions of type 1 
      CNV and PCV, while the proportions of type 2 CNV only and chorioretinal 
      anastomosis were similar between groups.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Coscas, Gabriel
AU  - Coscas G
AD  - Centre d'Ophtalmologie de Paris, Paris, France; Department of Ophthalmology, 
      University Paris-Est Creteil, Paris XII, Creteil, France. Electronic address: 
      gabriel.coscas@gmail.com.
FAU - Yamashiro, Kenji
AU  - Yamashiro K
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Coscas, Florence
AU  - Coscas F
AD  - Centre d'Ophtalmologie de Paris, Paris, France; Department of Ophthalmology, 
      University Paris-Est Creteil, Paris XII, Creteil, France.
FAU - De Benedetto, Umberto
AU  - De Benedetto U
AD  - Centre d'Ophtalmologie de Paris, Paris, France; Department of Ophthalmology, 
      University Paris-Est Creteil, Paris XII, Creteil, France.
FAU - Tsujikawa, Akitaka
AU  - Tsujikawa A
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Miyake, Masahiro
AU  - Miyake M
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Gemmy Cheung, Chui Ming
AU  - Gemmy Cheung CM
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, National 
      University of Singapore, Singapore.
FAU - Wong, Tien Yin
AU  - Wong TY
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, National 
      University of Singapore, Singapore.
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140517
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Diagnosis, Differential
MH  - Female
MH  - *Fluorescein Angiography
MH  - Follow-Up Studies
MH  - France/epidemiology
MH  - Fundus Oculi
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Male
MH  - Multimodal Imaging/*methods
MH  - Reproducibility of Results
MH  - Retinal Vessels/*pathology
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity
MH  - Wet Macular Degeneration/*diagnosis/epidemiology
EDAT- 2014/05/23 06:00
MHDA- 2014/10/15 06:00
CRDT- 2014/05/22 06:00
PHST- 2014/03/01 00:00 [received]
PHST- 2014/05/06 00:00 [revised]
PHST- 2014/05/06 00:00 [accepted]
PHST- 2014/05/22 06:00 [entrez]
PHST- 2014/05/23 06:00 [pubmed]
PHST- 2014/10/15 06:00 [medline]
AID - S0002-9394(14)00238-4 [pii]
AID - 10.1016/j.ajo.2014.05.004 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2014 Aug;158(2):309-318.e2. doi: 10.1016/j.ajo.2014.05.004. Epub 
      2014 May 17.