PMID- 24845072
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1752-8984 (Electronic)
IS  - 1479-1641 (Linking)
VI  - 11
IP  - 4
DP  - 2014 Jul
TI  - The DPP-4 inhibitor sitagliptin and endothelial function in patients with acute 
      coronary syndromes and newly detected glucose perturbations: A report from the 
      BEGAMI study.
PG  - 290-293
AB  - OBJECTIVE: Compromised endothelial function contributes to poor prognosis in 
      patients with coronary artery disease and type 2 diabetes. Incretin-based therapy 
      may exert beneficial cardiovascular effects beyond glucose lowering. We tested 
      whether sitagliptin improves endothelial function. RESEARCH DESIGN AND METHODS: 
      In the double-blind BEta-cell function in patients with Glucose Abnormalities and 
      Acute Myocardial Infarction (BEGAMI) trial, acute coronary syndrome 
      (ACS)-patients with newly detected impaired glucose tolerance (IGT) or type 2 
      diabetes mellitus (T2DM) were randomised to sitagliptin 100 mg (n = 31) or 
      placebo (n = 33) during 12 weeks. Endothelial function was studied as reactive 
      hyperaemia index (RHI). RESULTS: At baseline, the RHI was slightly compromised in 
      both groups (sitagliptin 1.67; Q1;Q3: 1.46;2.17 vs placebo 1.61; 1.44;1.96; ns). 
      The RHI did not change during the study period and was 1.57 (1.40;2.36) in the 
      sitagliptin and 1.60 (1.46;1.81; ns) in the placebo group after treatment. 
      CONCLUSION: Sitagliptin did not improve endothelial function in patients with ACS 
      and newly detected glucose perturbations.
CI  - (c) The Author(s) 2014.
FAU - Hage, Camilla
AU  - Hage C
AD  - Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden 
      Research Unit, Department of Cardiology, Karolinska University Hospital, 
      Stockholm, Sweden camilla.hage@karolinska.se.
FAU - Brismar, Kerstin
AU  - Brismar K
AD  - Endocrine and Diabetes Unit, Department of Molecular Medicine and Surgery, 
      Karolinska Institutet, Stockholm, Sweden.
FAU - Lundman, Pia
AU  - Lundman P
AD  - Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska 
      Institutet, Danderyd Hospital, Stockholm, Sweden.
FAU - Norhammar, Anna
AU  - Norhammar A
AD  - Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Ryden, Lars
AU  - Ryden L
AD  - Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Mellbin, Linda
AU  - Mellbin L
AD  - Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden 
      Research Unit, Department of Cardiology, Karolinska University Hospital, 
      Stockholm, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20140519
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - endothelial function
OT  - glucose
OT  - glucose perturbations
OT  - sitagliptin
EDAT- 2014/05/23 06:00
MHDA- 2014/05/23 06:00
CRDT- 2014/05/22 06:00
PHST- 2014/05/22 06:00 [entrez]
PHST- 2014/05/23 06:00 [pubmed]
PHST- 2014/05/23 06:00 [medline]
AID - 1479164114533355 [pii]
AID - 10.1177/1479164114533355 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2014 Jul;11(4):290-293. doi: 10.1177/1479164114533355. Epub 
      2014 May 19.