PMID- 24847189
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140521
LR  - 20220317
IS  - 1660-3796 (Print)
IS  - 1660-3818 (Electronic)
IS  - 1660-3796 (Linking)
VI  - 41
IP  - 2
DP  - 2014 Apr
TI  - The Royan Public Umbilical Cord Blood Bank: Does It Cover All Ethnic Groups in 
      Iran Based on HLA Diversity?
PG  - 134-8
LID - 10.1159/000357997 [doi]
AB  - BACKGROUND: Umbilical cord blood (UCB) stem cells allow the transplantation of 
      partially human leukocyte antigen (HLA)-matched grafts and are a valuable 
      resource for the treatment of hematologic malignancies and heritable hematologic, 
      immunologic and metabolic diseases, especially when a compatible bone marrow 
      donor is unavailable. The aim of this study was to determine how many ethnic 
      groups in Iran are covered by the available UCB units based on HLA diversity. 
      METHODS: From 2009 until mid-2013, 4,981 (30.3%) of the 16,437 UCB samples 
      collected met the storage criteria and were cryopreserved at a public cord blood 
      bank (CBB) in Tehran, Iran. HLA-A, -B and -DRB1 were typed in 1,793 samples. 
      RESULTS: The mean volume of the cryopreserved samples was 81.25 +/- 20.3 ml. The 
      range of total nucleated cells per unit was 51 x 10(7)-107 x 10(7). The most 
      common HLA alleles were HLA-A*2 (17%) and HLA-A*24 (15.6%), HLA-B*35 (16.8%) and 
      HLA-B*51 (13.9%), and HLA-DRB1*11 (20%) and HLA-DRB1*15 (14%). The predominant 
      haplotypes were HLA-A*24-B*35-DRB1*11 (2%), HLA-A*02-B*50-DR*07 (1.8%), and 
      HLA-A*02-B*51-DRB1*11 (1.5%). CONCLUSIONS: Based on the HLA-DRB1 profiles, the 
      UCB units available at the Royan public UCB bank are a potentially adequate 
      resource for hematopoietic stem cell transplantation for Iranian recipients 
      belonging to particular ethnic groups. Regular educational programs to improve 
      the public knowledge of UCB for transplantation can enhance the public CBB stocks 
      for all Iranian ethnic groups in the future.
FAU - Ebrahimkhani, Saeideh
AU  - Ebrahimkhani S
AD  - Department of Regenerative Medicine, Cell Science Research Center, Royan 
      Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
FAU - Farjadian, Shirin
AU  - Farjadian S
AD  - Department of Immunology, Shiraz University of Medical Sciences, Tehran, Iran.
FAU - Ebrahimi, Marzieh
AU  - Ebrahimi M
AD  - Department of Regenerative Medicine, Cell Science Research Center, Royan 
      Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran ; Department 
      of Stem Cells and Developmental Biology, Cell Science Research Center, Royan 
      Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20140217
PL  - Switzerland
TA  - Transfus Med Hemother
JT  - Transfusion medicine and hemotherapy : offizielles Organ der Deutschen 
      Gesellschaft fur Transfusionsmedizin und Immunhamatologie
JID - 101176417
PMC - PMC4025049
OTO - NOTNLM
OT  - HLA
OT  - Stem cell transplantation
OT  - Umbilical cord blood
EDAT- 2014/05/23 06:00
MHDA- 2014/05/23 06:01
PMCR- 2014/02/17
CRDT- 2014/05/22 06:00
PHST- 2013/08/06 00:00 [received]
PHST- 2013/09/03 00:00 [accepted]
PHST- 2014/05/22 06:00 [entrez]
PHST- 2014/05/23 06:00 [pubmed]
PHST- 2014/05/23 06:01 [medline]
PHST- 2014/02/17 00:00 [pmc-release]
AID - tmh-0041-0134 [pii]
AID - 10.1159/000357997 [doi]
PST - ppublish
SO  - Transfus Med Hemother. 2014 Apr;41(2):134-8. doi: 10.1159/000357997. Epub 2014 
      Feb 17.