PMID- 24847209
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 8
DP  - 2014
TI  - Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals.
PG  - 123
LID - 10.3389/fncel.2014.00123 [doi]
LID - 123
AB  - Connexins (Cxs) and Pannexins (Panx) form hemichannels at the plasma membrane of 
      animals. Despite their low open probability under physiological conditions, these 
      hemichannels release signaling molecules (i.e., ATP, Glutamate, PGE2) to the 
      extracellular space, thus subserving several important physiological processes. 
      Oxygen and CO2 sensing are fundamental to the normal functioning of vertebrate 
      organisms. Fluctuations in blood PO2, PCO2 and pH are sensed at the carotid 
      bifurcations of adult mammals by glomus cells of the carotid bodies. Likewise, 
      changes in pH and/or PCO2 of cerebrospinal fluid are sensed by central 
      chemoreceptors, a group of specialized neurones distributed in the ventrolateral 
      medulla (VLM), raphe nuclei, and some other brainstem areas. After many years of 
      research, the molecular mechanisms involved in chemosensing process are not 
      completely understood. This manuscript will review data regarding relationships 
      between chemosensitive cells and the expression of channels formed by Cxs and 
      Panx, with special emphasis on hemichannels.
FAU - Reyes, Edison Pablo
AU  - Reyes EP
AD  - Centro de Fisiologia Celular e Integrativa, Facultad de Medicina, Clinica Alemana 
      Universidad del Desarrollo Santiago, Chile ; Direccion de Investigacion, 
      Universidad Autonoma de Chile Santiago, Chile.
FAU - Cerpa, Veronica
AU  - Cerpa V
AD  - Centro de Fisiologia Celular e Integrativa, Facultad de Medicina, Clinica Alemana 
      Universidad del Desarrollo Santiago, Chile.
FAU - Corvalan, Liliana
AU  - Corvalan L
AD  - Centro de Fisiologia Celular e Integrativa, Facultad de Medicina, Clinica Alemana 
      Universidad del Desarrollo Santiago, Chile.
FAU - Retamal, Mauricio Antonio
AU  - Retamal MA
AD  - Centro de Fisiologia Celular e Integrativa, Facultad de Medicina, Clinica Alemana 
      Universidad del Desarrollo Santiago, Chile.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140509
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC4023181
OTO - NOTNLM
OT  - astrocytes
OT  - carotid body
OT  - connexins
OT  - gap junctions
OT  - glomus cells
OT  - hypercapnia
OT  - hypoxia
EDAT- 2014/05/23 06:00
MHDA- 2014/05/23 06:01
PMCR- 2014/01/01
CRDT- 2014/05/22 06:00
PHST- 2014/02/26 00:00 [received]
PHST- 2014/04/18 00:00 [accepted]
PHST- 2014/05/22 06:00 [entrez]
PHST- 2014/05/23 06:00 [pubmed]
PHST- 2014/05/23 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2014.00123 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2014 May 9;8:123. doi: 10.3389/fncel.2014.00123. eCollection 
      2014.