PMID- 24847328
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20220331
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 5
DP  - 2014
TI  - Metabolic control of dendritic cell activation and function: recent advances and 
      clinical implications.
PG  - 203
LID - 10.3389/fimmu.2014.00203 [doi]
LID - 203
AB  - Dendritic cells (DCs) are key regulators of both immunity and tolerance by 
      controlling activation and polarization of effector T helper cell and regulatory 
      T cell responses. Therefore, there is a major focus on developing approaches to 
      manipulate DC function for immunotherapy. It is well known that changes in 
      cellular activation are coupled to profound changes in cellular metabolism. Over 
      the past decade there is a growing appreciation that these metabolic changes also 
      underlie the capacity of immune cells to perform particular functions. This has 
      led to the concept that the manipulation of cellular metabolism can be used to 
      shape innate and adaptive immune responses. While most of our understanding in 
      this area has been gained from studies with T cells and macrophages, evidence is 
      emerging that the activation and function of DCs are also dictated by the type of 
      metabolism these cells commit to. We here discuss these new insights and explore 
      whether targeting of metabolic pathways in DCs could hold promise as a novel 
      approach to manipulate the functional properties of DCs for clinical purposes.
FAU - Everts, Bart
AU  - Everts B
AD  - Department of Pathology and Immunology, Washington University School of Medicine 
      , St. Louis, MO , USA ; Department of Parasitology, Leiden University Medical 
      Center , Leiden , Netherlands.
FAU - Pearce, Edward J
AU  - Pearce EJ
AD  - Department of Pathology and Immunology, Washington University School of Medicine 
      , St. Louis, MO , USA.
LA  - eng
GR  - R01 AI053825/AI/NIAID NIH HHS/United States
GR  - R01 CA164062/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20140508
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4021118
OTO - NOTNLM
OT  - TLR signaling
OT  - glycolysis
OT  - immunogenic dendritic cells
OT  - immunotherapy
OT  - metabolism
OT  - mitochondria
OT  - oxidative phosphorylation
OT  - tolerogenic dendritic cells
EDAT- 2014/05/23 06:00
MHDA- 2014/05/23 06:01
PMCR- 2014/01/01
CRDT- 2014/05/22 06:00
PHST- 2014/02/01 00:00 [received]
PHST- 2014/04/24 00:00 [accepted]
PHST- 2014/05/22 06:00 [entrez]
PHST- 2014/05/23 06:00 [pubmed]
PHST- 2014/05/23 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2014.00203 [doi]
PST - epublish
SO  - Front Immunol. 2014 May 8;5:203. doi: 10.3389/fimmu.2014.00203. eCollection 2014.