PMID- 24847342
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140521
LR  - 20240410
IS  - 1664-462X (Print)
IS  - 1664-462X (Electronic)
IS  - 1664-462X (Linking)
VI  - 5
DP  - 2014
TI  - Role of NPR1 and KYP in long-lasting induced resistance by beta-aminobutyric acid.
PG  - 184
LID - 10.3389/fpls.2014.00184 [doi]
LID - 184
AB  - Priming of defense increases the responsiveness of the plant immune system and 
      can provide broad-spectrum protection against disease. Recent evidence suggests 
      that priming of defense can be inherited epigenetically to following generations. 
      However, the mechanisms of long-lasting defense priming within one generation 
      remains poorly understood. Here, we have investigated the mechanistic basis of 
      long-lasting induced resistance after treatment with beta -aminobutyric acid (BABA), 
      an agent that mimics biologically induced resistance phenomena. BABA-induced 
      resistance (BABA-IR) is based on priming of salicylic acid (SA)-dependent and 
      SA-independent defenses. BABA-IR could be detected up to 28 days after treatment 
      of wild-type Arabidopsis. This long-lasting component of the induced resistance 
      response requires the regulatory protein NPR1 and is associated with priming of 
      SA-inducible genes. In contrast, NPR1-independent resistance by BABA was 
      transient and had disappeared by 14 days after treatment. Chromatin 
      immunoprecipitation (ChIP) assays revealed no increased acetylation of histone 
      H3K9 at promoters regions of priming-responsive genes, indicating that this 
      post-translational histone modification is not critical for long-term 
      transcriptional priming. Interestingly, the kyp-6 mutant, which is affected in 
      methyltransferase activity of H3K9, was blocked in long-lasting BABA-IR, 
      indicating a critical requirement of this post-translational histone modification 
      in long-lasting BABA-IR. Considering that KYP suppresses gene transcription 
      through methylation of H3K9 and CpHpG DNA methylation, we propose that KYP 
      enables long-term defense gene priming by silencing suppressor genes of 
      SA/NPR1-dependent genes.
FAU - Luna, Estrella
AU  - Luna E
AD  - Department of Animal and Plant Sciences, The University of Sheffield Sheffield, 
      UK.
FAU - Lopez, Ana
AU  - Lopez A
AD  - Department of Animal and Plant Sciences, The University of Sheffield Sheffield, 
      UK.
FAU - Kooiman, Jaap
AU  - Kooiman J
AD  - Department of Animal and Plant Sciences, The University of Sheffield Sheffield, 
      UK ; Department of Biology, Utrecht University Utrecht, Netherlands.
FAU - Ton, Jurriaan
AU  - Ton J
AD  - Department of Animal and Plant Sciences, The University of Sheffield Sheffield, 
      UK.
LA  - eng
GR  - 309944/ERC_/European Research Council/International
PT  - Journal Article
DEP - 20140508
PL  - Switzerland
TA  - Front Plant Sci
JT  - Frontiers in plant science
JID - 101568200
PMC - PMC4021125
OTO - NOTNLM
OT  - Arabidopsis
OT  - KYP
OT  - NPR1
OT  - induced defense
OT  - priming
EDAT- 2014/05/23 06:00
MHDA- 2014/05/23 06:01
PMCR- 2014/01/01
CRDT- 2014/05/22 06:00
PHST- 2014/03/05 00:00 [received]
PHST- 2014/04/19 00:00 [accepted]
PHST- 2014/05/22 06:00 [entrez]
PHST- 2014/05/23 06:00 [pubmed]
PHST- 2014/05/23 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fpls.2014.00184 [doi]
PST - epublish
SO  - Front Plant Sci. 2014 May 8;5:184. doi: 10.3389/fpls.2014.00184. eCollection 
      2014.