PMID- 24848795
OWN - NLM
STAT- MEDLINE
DCOM- 20150115
LR  - 20220330
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 5
DP  - 2014
TI  - Repetitive long-term hyperbaric oxygen treatment (HBOT) administered after 
      experimental traumatic brain injury in rats induces significant remyelination and 
      a recovery of sensorimotor function.
PG  - e97750
LID - 10.1371/journal.pone.0097750 [doi]
LID - e97750
AB  - Cells in the central nervous system rely almost exclusively on aerobic 
      metabolism. Oxygen deprivation, such as injury-associated ischemia, results in 
      detrimental apoptotic and necrotic cell loss. There is evidence that repetitive 
      hyperbaric oxygen therapy (HBOT) improves outcomes in traumatic brain-injured 
      patients. However, there are no experimental studies investigating the mechanism 
      of repetitive long-term HBOT treatment-associated protective effects. We have 
      therefore analysed the effect of long-term repetitive HBOT treatment on brain 
      trauma-associated cerebral modulations using the lateral fluid percussion model 
      for rats. Trauma-associated neurological impairment regressed significantly in 
      the group of HBO-treated animals within three weeks post trauma. Evaluation of 
      somatosensory-evoked potentials indicated a possible remyelination of neurons in 
      the injured hemisphere following HBOT. This presumption was confirmed by a 
      pronounced increase in myelin basic protein isoforms, PLP expression as well as 
      an increase in myelin following three weeks of repetitive HBO treatment. Our 
      results indicate that protective long-term HBOT effects following brain injury is 
      mediated by a pronounced remyelination in the ipsilateral injured cortex as 
      substantiated by the associated recovery of sensorimotor function.
FAU - Kraitsy, Klaus
AU  - Kraitsy K
AD  - Research Unit for Experimental Neurotraumatology, Medical University of Graz, 
      Graz, Austria.
FAU - Uecal, Muammer
AU  - Uecal M
AD  - Research Unit for Experimental Neurotraumatology, Medical University of Graz, 
      Graz, Austria.
FAU - Grossauer, Stefan
AU  - Grossauer S
AD  - Department of Neurosurgery, Medical University of Graz, Graz, Austria.
FAU - Bruckmann, Lukas
AU  - Bruckmann L
AD  - Department of Neurosurgery, Medical University of Graz, Graz, Austria.
FAU - Pfleger, Florentina
AU  - Pfleger F
AD  - Research Unit for Experimental Neurotraumatology, Medical University of Graz, 
      Graz, Austria.
FAU - Ropele, Stefan
AU  - Ropele S
AD  - Clinical Division of General Neurology, Medical University of Graz, Graz, 
      Austria.
FAU - Fazekas, Franz
AU  - Fazekas F
AD  - Clinical Division of General Neurology, Medical University of Graz, Graz, 
      Austria.
FAU - Gruenbacher, Gerda
AU  - Gruenbacher G
AD  - Research Unit for Experimental Neurotraumatology, Medical University of Graz, 
      Graz, Austria.
FAU - Patz, Silke
AU  - Patz S
AD  - Research Unit for Experimental Neurotraumatology, Medical University of Graz, 
      Graz, Austria.
FAU - Absenger, Markus
AU  - Absenger M
AD  - Core Facility Microscopy, Centre for Medical Research, Medical University of 
      Graz, Graz, Austria.
FAU - Porubsky, Christian
AU  - Porubsky C
AD  - Division of Thoracic and Hyperbaric Surgery, Department of Surgery, Medical 
      University of Graz, Graz, Austria.
FAU - Smolle-Juettner, Freyja
AU  - Smolle-Juettner F
AD  - Division of Thoracic and Hyperbaric Surgery, Department of Surgery, Medical 
      University of Graz, Graz, Austria.
FAU - Tezer, Irem
AU  - Tezer I
AD  - Division of Thoracic and Hyperbaric Surgery, Department of Surgery, Medical 
      University of Graz, Graz, Austria.
FAU - Molcanyi, Marek
AU  - Molcanyi M
AD  - Department of Neurosurgery, University of Cologne, Cologne, Germany; Institute of 
      Neurophysiology, University of Cologne, Cologne, Germany.
FAU - Fasching, Ulrike
AU  - Fasching U
AD  - Research Unit for Experimental Neurotraumatology, Medical University of Graz, 
      Graz, Austria.
FAU - Schaefer, Ute
AU  - Schaefer U
AD  - Research Unit for Experimental Neurotraumatology, Medical University of Graz, 
      Graz, Austria.
LA  - eng
PT  - Journal Article
DEP - 20140521
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Brain/pathology/physiopathology
MH  - Brain Injuries/pathology/*physiopathology/*therapy
MH  - Evoked Potentials
MH  - *Hyperbaric Oxygenation
MH  - Male
MH  - Myelin Sheath/*physiology
MH  - *Psychomotor Performance
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Recovery of Function
MH  - Time Factors
PMC - PMC4029808
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/05/23 06:00
MHDA- 2015/01/16 06:00
PMCR- 2014/05/21
CRDT- 2014/05/23 06:00
PHST- 2014/01/13 00:00 [received]
PHST- 2014/04/24 00:00 [accepted]
PHST- 2014/05/23 06:00 [entrez]
PHST- 2014/05/23 06:00 [pubmed]
PHST- 2015/01/16 06:00 [medline]
PHST- 2014/05/21 00:00 [pmc-release]
AID - PONE-D-14-01427 [pii]
AID - 10.1371/journal.pone.0097750 [doi]
PST - epublish
SO  - PLoS One. 2014 May 21;9(5):e97750. doi: 10.1371/journal.pone.0097750. eCollection 
      2014.