PMID- 24849421
OWN - NLM
STAT- MEDLINE
DCOM- 20150909
LR  - 20190221
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 34
IP  - 5
DP  - 2014 May
TI  - [Value of assessing left ventricular longitudinal systolic peak strain in 
      differential diagnosis of primary cardiac amyloidosis from hypertrophic 
      cardiomyopathy].
PG  - 609-16
AB  - OBJECTIVE: To analyze the endocardial, myocardial, and epicardial longitudinal 
      systolic strain (LSsys) in the left ventricle (LV) segments and walls in patients 
      with cardiac involvement due to primary amyloidosis (AL-CA) and hypertrophic 
      cardiomyopathy (HCM). METHODS: Twenty patients with biopsy-proven AL-CA, 20 with 
      asymmetric HCM, and 20 age-matched healthy volunteers were analyzed for their 
      clinical characteristics and underwent conventional echocardiography for 
      evaluating LV wall thickness, left atrial and ventricle size, systolic and 
      diastolic function and 2-dimensional velocity vector imaging for evaluating the 
      endocardial, myocardial and epicardial LSsys of the LV segments and walls. AL-CA 
      and HCM patients also underwent cardiac magnetic resonance to evaluate the late 
      gadolinium enhancement (LGE) features. RESULTS: Compared with the control group, 
      AL-CA and HCM groups, with similar clinical symptoms and physical signs, both 
      showed increased LV wall thickness, left atrial diameter, E/A ratio, septal E/e' 
      ratio and the prevalence of granular sparkling. LV segments and walls endocardial 
      LSsys were significantly lower in AL-CA patients than in HCM patients and the 
      control subjects. The endocardial-epicardial LSsys difference in all the left 
      ventricle walls were significantly smaller in AL-CA group than in the control 
      group, but this difference appeared variable in HCM group. The LGE also presented 
      with different features in AL-CA and HCM: AL-CA group showed subendocardial LGE 
      in almost all the LV walls, but HCM group showed patchy LGE with a regional, 
      multifocal distribution. CONCLUSION: AL-CA is characterized by a significantly 
      reduced endocardial LSsys in the LV segments and an uniform decrease of the 
      endocardial-epicardial LSsys difference in all the LV walls, but the changes in 
      HCM appear variable, and 2-dimensional velocity vector imaging is therefore a 
      useful modality to differentiate AL-CA from HCM.
FAU - Zhang, Lu
AU  - Zhang L
AD  - Department of Cardiology, 2Department of Radiology, 3Institute of Geriatrics, 
      General Hospital of PLA, Beijing 100853, China. E-mail: lucy_victor@sina.com.
FAU - Wang, Ye
AU  - Wang Y
FAU - Cheng, Liuquan
AU  - Cheng L
FAU - Wang, Jing
AU  - Wang J
FAU - Zhou, Xiao
AU  - Zhou X
FAU - Liu, Miao
AU  - Liu M
FAU - Zhang, Wei
AU  - Zhang W
FAU - Zhang, Ming
AU  - Zhang M
FAU - Zhang, Bo
AU  - Zhang B
FAU - Zhi, Guang
AU  - Zhi G
LA  - chi
PT  - Journal Article
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
SB  - IM
MH  - Amyloidosis/*diagnosis
MH  - Cardiomyopathy, Hypertrophic/*diagnosis
MH  - *Diagnosis, Differential
MH  - Diastole
MH  - Echocardiography
MH  - Heart Ventricles/*physiopathology
MH  - Humans
MH  - Immunoglobulin Light-chain Amyloidosis
MH  - *Systole
EDAT- 2014/05/23 06:00
MHDA- 2015/09/10 06:00
CRDT- 2014/05/23 06:00
PHST- 2014/05/23 06:00 [entrez]
PHST- 2014/05/23 06:00 [pubmed]
PHST- 2015/09/10 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2014 May;34(5):609-16.