PMID- 24849430
OWN - NLM
STAT- MEDLINE
DCOM- 20150909
LR  - 20181202
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 34
IP  - 5
DP  - 2014 May
TI  - [Detection of fetal chromosomal aneuploidy in pregnant women at advanced maternal 
      age during the first trimester].
PG  - 655-8
AB  - OBJECTIVE: To investigate the value of maternal plasma cell-free fetal DNA 
      (cff-DNA) examination in detection of fetal chromosomal aneuploidy in pregnant 
      women at advanced maternal ages during the first trimester of pregnancy. METHODS: 
      A total of 136 pregnant women (11 to 13+6 gestational weeks) with advanced 
      maternal ages were screened for fetal chromosomal aneuploidy with ultrasound and 
      maternal plasma cff-DNA examination during March 1, 2011 to August 31, 2013, and 
      the results were then confirmed by karyotype analysis and fluorescence in situ 
      hybridization (FISH). RESULTS: Of the 136 women examined, cff-DNA screening 
      detected chromosomal aneuploidy in 5 cases, including trisome-21 in 3 cases, 
      trisome-18 in 1 case, and 45,X in 1 case as confirmed subsequently by karyotype 
      analysis. Ultrasound screening reported a normal finding in one case of 
      trisomy-21, thickening of the NT in the case of trisomy-18, and fetal anasarca in 
      the case of 45,X. Karyotype analysis and follow-up of the women did not find 
      chromosomal abnormality in the 131 negative cases screened by cff-DNA detection. 
      CONCLUSION: Screening of material plasma cff-DNA allows accurate and early 
      detection of fetal chromosomal aneuploidy in women of advanced maternal ages to 
      avoid unnecessary invasive antenatal examinations.
FAU - Wang, Shujuan
AU  - Wang S
AD  - Department of Obstetrics and Gynecology, General Hospital of PLA, Beijing 100853, 
      China. E-mail: dch853@126.com.
FAU - Gao, Zhiying
AU  - Gao Z
FAU - Lu, Yanping
AU  - Lu Y
FAU - Li, Yali
AU  - Li Y
FAU - Jiang, Shufang
AU  - Jiang S
FAU - Wang, Longxia
AU  - Wang L
FAU - Zhang, Liwen
AU  - Zhang L
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - *Aneuploidy
MH  - Chromosomes, Human, Pair 18
MH  - DNA/blood
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - *Maternal Age
MH  - Pregnancy
MH  - *Pregnancy Trimester, First
MH  - Prenatal Diagnosis
MH  - Trisomy
EDAT- 2014/05/23 06:00
MHDA- 2015/09/10 06:00
CRDT- 2014/05/23 06:00
PHST- 2014/05/23 06:00 [entrez]
PHST- 2014/05/23 06:00 [pubmed]
PHST- 2015/09/10 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2014 May;34(5):655-8.