PMID- 24850928
OWN - NLM
STAT- MEDLINE
DCOM- 20150114
LR  - 20211021
IS  - 1471-2954 (Electronic)
IS  - 0962-8452 (Print)
IS  - 0962-8452 (Linking)
VI  - 281
IP  - 1786
DP  - 2014 Jul 7
TI  - Hypoxia-inducible factor-1 mediates adaptive developmental plasticity of hypoxia 
      tolerance in zebrafish, Danio rerio.
LID - 10.1098/rspb.2014.0637 [doi]
LID - 20140637
AB  - In recent years, natural and anthropogenic factors have increased aquatic hypoxia 
      the world over. In most organisms, the cellular response to hypoxia is mediated 
      by the master regulator hypoxia-inducible factor-1 (HIF-1). HIF-1 also plays a 
      critical role in the normal development of the cardiovascular system of 
      vertebrates. We tested the hypothesis that hypoxia exposures which resulted in 
      HIF-1 induction during embryogenesis would be associated with enhanced hypoxia 
      tolerance in subsequent developmental stages. We exposed zebrafish (Danio rerio) 
      embryos to just 4 h of severe hypoxia or total anoxia at 18, 24 and 36 h 
      post-fertilization (hpf). Of these, exposure to hypoxia at 24 and 36 hpf as well 
      as anoxia at 36 hpf activated the HIF-1 cellular pathway. Zebrafish embryos that 
      acutely upregulated the HIF-1 pathway had an increased hypoxia tolerance as 
      larvae. The critical window for hypoxia sensitivity and HIF-1 signalling was 24 
      hpf. Adult male fish had a lower critical oxygen tension (Pcrit) compared with 
      females. Early induction of HIF-1 correlated directly with an increased 
      proportion of males in the population. We conclude that mounting a HIF-1 response 
      during embryogenesis is associated with long-term impacts on the phenotype of 
      later stages which could influence both individual hypoxia tolerance and 
      population dynamics.
CI  - (c) 2014 The Author(s) Published by the Royal Society. All rights reserved.
FAU - Robertson, Cayleih E
AU  - Robertson CE
AD  - Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada.
FAU - Wright, Patricia A
AU  - Wright PA
AD  - Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada.
FAU - Koblitz, Louise
AU  - Koblitz L
AD  - Institute of Zoology, University of Innsbruck, Innsbruck, Austria.
FAU - Bernier, Nicholas J
AU  - Bernier NJ
AD  - Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada 
      nbernier@uoguelph.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Proc Biol Sci
JT  - Proceedings. Biological sciences
JID - 101245157
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Anaerobiosis
MH  - Animals
MH  - Embryo, Nonmammalian/embryology/physiology
MH  - Female
MH  - Hypoxia-Inducible Factor 1/*genetics/metabolism
MH  - Larva/genetics/growth & development/physiology
MH  - Male
MH  - Oxygen/*metabolism
MH  - Zebrafish/embryology/genetics/growth & development/*physiology
PMC - PMC4046416
OTO - NOTNLM
OT  - Hypoxia-inducible factor-1 cellular pathway
OT  - developmental plasticity
OT  - hypoxia tolerance
OT  - sex ratio bias
OT  - zebrafish
EDAT- 2014/05/23 06:00
MHDA- 2015/01/15 06:00
PMCR- 2015/07/07
CRDT- 2014/05/23 06:00
PHST- 2014/05/23 06:00 [entrez]
PHST- 2014/05/23 06:00 [pubmed]
PHST- 2015/01/15 06:00 [medline]
PHST- 2015/07/07 00:00 [pmc-release]
AID - rspb.2014.0637 [pii]
AID - rspb20140637 [pii]
AID - 10.1098/rspb.2014.0637 [doi]
PST - ppublish
SO  - Proc Biol Sci. 2014 Jul 7;281(1786):20140637. doi: 10.1098/rspb.2014.0637.