PMID- 24851119
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140522
LR  - 20220316
IS  - 1738-1088 (Print)
IS  - 2093-4327 (Electronic)
IS  - 1738-1088 (Linking)
VI  - 12
IP  - 1
DP  - 2014 Apr
TI  - Duloxetine, a Selective Noradrenaline Reuptake Inhibitor, Increased Plasma Levels 
      of 3-Methoxy-4-hydroxyphenylglycol but Not Homovanillic Acid in Patients with 
      Major Depressive Disorder.
PG  - 37-40
LID - 10.9758/cpn.2014.12.1.37 [doi]
AB  - OBJECTIVE: We investigated the effects of duloxetine on the plasma levels of 
      catecholamine metabolites and serum brain-derived neurotrophic factor (BDNF) in 
      64 patients with major depressive disorder (MDD). METHODS: Major depressive 
      episode was diagnosed using the Structured Clinical Interview for the Diagnostic 
      and Statistical Manual of Mental Disorders-fourth edition (DSM-IV) according to 
      the DSM-IV text revision (DSM-IV-TR) criteria. The severity of depression was 
      evaluated using the 17-item Hamilton Rating Scale for Depression (HAMD-17). Blood 
      sampling and clinical evaluation were performed on days 0, 28, and 56. RESULTS: 
      Duloxetine treatment for 8 weeks significantly increased the plasma 
      3-methoxy-4-hydroxyphenylglycol (MHPG) levels but not the homovanillic acid (HVA) 
      levels in responders with MDD. CONCLUSION: These results imply that noradrenaline 
      plays an important role in alleviating depressive symptoms.
FAU - Atake, Kiyokazu
AU  - Atake K
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Yoshimura, Reiji
AU  - Yoshimura R
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Hori, Hikaru
AU  - Hori H
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Katsuki, Asuka
AU  - Katsuki A
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Ikenouchi-Sugita, Atsuko
AU  - Ikenouchi-Sugita A
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Umene-Nakano, Wakako
AU  - Umene-Nakano W
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Nakamura, Jun
AU  - Nakamura J
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140424
PL  - Korea (South)
TA  - Clin Psychopharmacol Neurosci
JT  - Clinical psychopharmacology and neuroscience : the official scientific journal of 
      the Korean College of Neuropsychopharmacology
JID - 101207332
PMC - PMC4022764
OTO - NOTNLM
OT  - 3-Methoxy-4-hydroxyphenylglycol
OT  - Brain-derived neurotrophic factor
OT  - Duloxetine
OT  - Homovanillic acid
OT  - Major depressive disorder
EDAT- 2014/05/23 06:00
MHDA- 2014/05/23 06:01
PMCR- 2014/04/01
CRDT- 2014/05/23 06:00
PHST- 2013/04/09 00:00 [received]
PHST- 2013/06/13 00:00 [revised]
PHST- 2013/08/06 00:00 [accepted]
PHST- 2014/05/23 06:00 [entrez]
PHST- 2014/05/23 06:00 [pubmed]
PHST- 2014/05/23 06:01 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - 10.9758/cpn.2014.12.1.37 [doi]
PST - ppublish
SO  - Clin Psychopharmacol Neurosci. 2014 Apr;12(1):37-40. doi: 
      10.9758/cpn.2014.12.1.37. Epub 2014 Apr 24.