PMID- 24851891
OWN - NLM
STAT- MEDLINE
DCOM- 20150205
LR  - 20140523
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 94
IP  - 14
DP  - 2014 Apr 15
TI  - [Value of cardiopulmonary exercise test in cardiac function evaluation of 
      patients with chronic left heart failure caused by dilated cardiomyopathy].
PG  - 1076-9
AB  - OBJECTIVE: To assess the value of cardiopulmonary exercise test in the evaluation 
      of cardiac function in patients with chronic left heart failure caused by dilated 
      cardiomyopathy. METHODS: Fifty-three inpatients aged 18 year and over with 
      chronic left heart failure caused by dilated cardiomyopathy at Fuwai Hospital 
      from October 2010 to October 2011 were selected and divided into 2 groups 
      according to the New York Heart Association (NYHA) heart function classification. 
      One group had 20 cases for class II and another 33 cases for class III-IV. All of 
      them received cardiopulmonary exercise tests. Synchronous measurement and record 
      of gas exchange indices were taken during every breath, and so were heart rate, 
      blood pressure, electrocardiogram and blood oxygen saturation. At the same time, 
      other routine tests were also performed. After exercise test, anaerobic threshold 
      and peak oxygen consumption indices were calculated and statistically analyzed. 
      They also received subsequent follow-ups of 1 day, 1 week, 1 month, 6 months and 
      1 year, including activities, clinical manifestations and cardiac adverse events. 
      RESULTS: At baseline, the differences in gender, age, body mass index, concurrent 
      diseases, left ventricular end-diastolic diameter, left ventricular ejection 
      fraction and serum creatinine had no statistical significance (P > 0.05). 
      Compared with cardiac function class II group, the class III-IV group had higher 
      left atrial diameter, level of amino terminal pro-B-type natriuretic peptide 
      (NT-proBNP), incidence of atrial fibrillation ((51.4 +/- 7.5) vs (43.6 +/- 7.7) mm, 
      (2 607 +/- 1 782) vs (1 312 +/- 901) microg/L, 42.4% (14/33) vs 5.0% (1/20)) and lower 
      glomerular filtration rate, peak oxygen consumption, levels of anaerobic 
      threshold ((72 +/- 20) vs (97 +/- 23) ml/min, (13.7 +/- 2.6) vs (20.5 +/- 3.6) 
      ml.min(-1).kg(-1), (10.7 +/- 1.5) vs (13.3 +/- 2.1) ml.min(-1).kg(-1)) (all P < 
      0.01). And NT-proBNP and cardiac function classification showed a positive 
      correlation (OR = 1.002, P = 0.003) while peak oxygen consumption, anaerobic 
      threshold and cardiac function classification were negatively correlated (OR = 
      0.736, 0.608; P = 0.011, 0.001). CONCLUSIONS: Cardiopulmonary exercise test 
      objectively reflects the cardiopulmonary reserve of heart failure patients with 
      dilated cardiomyopathy. And the parameters of anaerobic threshold and peak oxygen 
      consumption may reflect the patient's motor ability quantitatively and 
      accurately.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Cardiology, Fuwai Hospital, Peking Union Medical College, Chinese 
      Academy of Medical Science, Beijing 100037, China.
FAU - Huang, Jie
AU  - Huang J
AD  - Email: huanjie@medmail.com.cn.
FAU - Xu, Haiyan
AU  - Xu H
FAU - Zhang, Shu
AU  - Zhang S
FAU - Liu, Zhihong
AU  - Liu Z
FAU - Liao, Zhongkai
AU  - Liao Z
FAU - Ma, Xiuping
AU  - Ma X
FAU - Liu, Qing
AU  - Liu Q
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Dilated/complications/*physiopathology
MH  - Chronic Disease
MH  - *Exercise Test
MH  - Female
MH  - Heart Failure/diagnosis/etiology/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption
MH  - Ventricular Function, Left
MH  - Young Adult
EDAT- 2014/05/24 06:00
MHDA- 2015/02/06 06:00
CRDT- 2014/05/24 06:00
PHST- 2014/05/24 06:00 [entrez]
PHST- 2014/05/24 06:00 [pubmed]
PHST- 2015/02/06 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2014 Apr 15;94(14):1076-9.