PMID- 24852100
OWN - NLM
STAT- MEDLINE
DCOM- 20141217
LR  - 20191210
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 261
DP  - 2014 Nov
TI  - Defeating the fear: new insights into the neurobiology of stress susceptibility.
PG  - 412-6
LID - S0014-4886(14)00154-X [pii]
LID - 10.1016/j.expneurol.2014.05.012 [doi]
AB  - The psychopathological impact of emotional stress on a specific individual varies 
      markedly: while most escape the development of post-traumatic stress disorder 
      and/or major depression, a select group of individuals demonstrate a 
      vulnerability to succumb to these conditions. The past decade has witnessed an 
      explosion in animal research into the underlying neurobiological mechanisms that 
      govern both vulnerability and resilience to such stressors. In the May 2014 
      issue, Chou and colleagues employ the mouse social defeat model of chronic stress 
      to demonstrate that defeated susceptible mice display an exaggerated conditioned 
      fear response associated with more pronounced autonomic changes. These 
      physiological alterations were found to be mediated via local increases in the 
      levels of brain derived neurotrophic factor (BDNF) within the basolateral 
      amygdala and could be inhibited by the systemic administration of a beta 
      adrenergic antagonist. This mini-review critically examines this manuscript's new 
      mechanistic insights in light of previous results employing similar approaches. 
      The strengths and limitations of the social defeat model, as well as the 
      relevance of these findings to neurologic illness are discussed briefly.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Krishnan, Vaishnav
AU  - Krishnan V
AD  - Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline 
      Avenue, Boston, MA 02215, USA. Electronic address: vkrish@bidmc.harvard.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140520
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Conditioning, Psychological
MH  - *Disease Susceptibility
MH  - Fear/*psychology
MH  - Humans
MH  - Mice
MH  - *Neurobiology
MH  - *Stress, Psychological/etiology/pathology/psychology
EDAT- 2014/05/24 06:00
MHDA- 2014/12/18 06:00
CRDT- 2014/05/24 06:00
PHST- 2014/03/16 00:00 [received]
PHST- 2014/05/08 00:00 [revised]
PHST- 2014/05/12 00:00 [accepted]
PHST- 2014/05/24 06:00 [entrez]
PHST- 2014/05/24 06:00 [pubmed]
PHST- 2014/12/18 06:00 [medline]
AID - S0014-4886(14)00154-X [pii]
AID - 10.1016/j.expneurol.2014.05.012 [doi]
PST - ppublish
SO  - Exp Neurol. 2014 Nov;261:412-6. doi: 10.1016/j.expneurol.2014.05.012. Epub 2014 
      May 20.