PMID- 24852190
OWN - NLM
STAT- MEDLINE
DCOM- 20150119
LR  - 20140610
IS  - 1421-9794 (Electronic)
IS  - 0009-3157 (Linking)
VI  - 59
IP  - 5
DP  - 2013
TI  - Human herpesvirus 6 encephalitis simulating brain metastases in a patient with 
      advanced small-cell lung cancer.
PG  - 385-6
LID - 10.1159/000360616 [doi]
AB  - BACKGROUND: The brain is a frequent site of metastases in small-cell lung cancer. 
      Symptoms of cerebral involvement are headache, disorientation, nausea/vomiting 
      and seizures. CASE: A man with small-cell lung cancer developed a human 
      herpesvirus 6 (HHV-6) meningoencephalitis with neurological symptoms that 
      simulated brain involvement from the lung cancer. HHV-6 is a T cell lymphotropic 
      virus which may be pathogenic in the immunocompromised host. HHV-6 remains latent 
      after the first infection, and when the immune system is compromised it can 
      reactivate. The treatment of HHV-6 infection is highly specific and the drugs 
      recommended are the two antivirals, ganciclovir or foscarnet. CONCLUSION: In 
      cancer patients neurologic symptoms are usually due to brain metastases. This 
      case shows that in a cancer patient any aspecific neurologic symptom should be 
      carefully evaluated in order to exclude a non-oncologic cause. This statement is 
      particularly true if the therapies for the oncological and neurological diseases 
      are effective.
FAU - Mordenti, Patrizia
AU  - Mordenti P
AD  - Dipartimento Oncologia-Ematologia, Ospedale Guglielmo da Saliceto, Piacenza, 
      Italy.
FAU - Zaffignani, Elena
AU  - Zaffignani E
FAU - Immovilli, Paolo
AU  - Immovilli P
FAU - Nobili, Elisabetta
AU  - Nobili E
FAU - Cavanna, Luigi
AU  - Cavanna L
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20140513
PL  - Switzerland
TA  - Chemotherapy
JT  - Chemotherapy
JID - 0144731
RN  - 0 (Antiviral Agents)
RN  - 364P9RVW4X (Foscarnet)
RN  - P9G3CKZ4P5 (Ganciclovir)
RN  - Human Herpesvirus 6 encephalitis
SB  - IM
MH  - Antiviral Agents/therapeutic use
MH  - Brain Neoplasms/*diagnosis/secondary
MH  - Encephalitis, Viral/*diagnosis/drug therapy/physiopathology
MH  - Foscarnet/therapeutic use
MH  - Ganciclovir/therapeutic use
MH  - Herpesvirus 6, Human/isolation & purification
MH  - Humans
MH  - Immunocompromised Host
MH  - Lung Neoplasms/*pathology
MH  - Male
MH  - Middle Aged
MH  - Roseolovirus Infections/*diagnosis/drug therapy/physiopathology
MH  - Small Cell Lung Carcinoma/*pathology
EDAT- 2014/05/24 06:00
MHDA- 2015/01/20 06:00
CRDT- 2014/05/24 06:00
PHST- 2013/09/25 00:00 [received]
PHST- 2014/02/13 00:00 [accepted]
PHST- 2014/05/24 06:00 [entrez]
PHST- 2014/05/24 06:00 [pubmed]
PHST- 2015/01/20 06:00 [medline]
AID - 000360616 [pii]
AID - 10.1159/000360616 [doi]
PST - ppublish
SO  - Chemotherapy. 2013;59(5):385-6. doi: 10.1159/000360616. Epub 2014 May 13.