PMID- 24852404
OWN - NLM
STAT- MEDLINE
DCOM- 20150127
LR  - 20140619
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 78
IP  - 3
DP  - 2014 Jul
TI  - Probing the impact of sex steroids and menopause-related sex steroid deprivation 
      on modulation of immune senescence.
PG  - 174-8
LID - S0378-5122(14)00133-9 [pii]
LID - 10.1016/j.maturitas.2014.04.014 [doi]
AB  - Immune senescence denotes the general decline in immune system function, 
      characterized by a reduced immune response and an increased inflammatory state. 
      Menopause is a natural change in a women's life, the menopause-related low 
      estrogen levels affecting many body functions, among them the immune system. 
      Numerous human studies with menopausal women and animal models with surgically 
      induced menopause show a clear impact of sex steroids in immune responses. Female 
      superiority in vaccination response and predisposition to infections are 
      eliminated after menopause, while during menopause inflammatory cytokines such as 
      Tumor Necrosis Factor-alpha (TNF-alpha), Interleukins-1beta, 6, 8 and 13 (IL-1beta, IL-6, IL-8, 
      IL-13) and Monocyte Chemoattractant Protein-1 (MCP-1) are increased, implying a 
      molecular connection of sex steroid loss with immune senescence. Moreover, immune 
      cells modify their number and function after the menopausal transition, this 
      offering another explanation for immune senescence. Until now most of the 
      existing studies have concluded that menopause plays an additional role to aging 
      in immune senescence. While it is clear that we are as yet far from thoroughly 
      understanding the molecular pathways connecting sex steroids and menopause with 
      immune senescence, such knowledge is highly likely to enable future targeted 
      interventions in treatment and prevention of age-related diseases in women.
CI  - Copyright (c) 2014. Published by Elsevier Ireland Ltd.
FAU - Vrachnis, Nikolaos
AU  - Vrachnis N
AD  - 2nd Department of Obstetrics and Gynecology, University of Athens Medical School, 
      Aretaieio Hospital, Athens, Greece. Electronic address: nvrachnis@hotmail.com.
FAU - Zygouris, Dimitrios
AU  - Zygouris D
AD  - University of Athens Medical School, Athens, Greece. Electronic address: 
      zyg14@hotmail.com.
FAU - Iliodromiti, Zoe
AU  - Iliodromiti Z
AD  - Department of Neonatology, University of Athens Medical School, Aretaieio 
      Hospital, Athens, Greece.
FAU - Daniilidis, Angelos
AU  - Daniilidis A
AD  - Department of Obstetrics and Gynecology, University of Thessaloniki Medical 
      School, Ippokrateio Hospital, Thessaloniki, Greece.
FAU - Valsamakis, Georgios
AU  - Valsamakis G
AD  - 2nd Department of Obstetrics and Gynecology, University of Athens Medical School, 
      Aretaieio Hospital, Athens, Greece.
FAU - Kalantaridou, Sophia
AU  - Kalantaridou S
AD  - Department of Obstetrics and Gynecology, University of Ioannina Medical School, 
      Ioannina University Hospital, Ioannina, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140501
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
RN  - 0 (Cytokines)
RN  - 0 (Estrogens)
SB  - IM
MH  - *Aging
MH  - Cytokines/*metabolism
MH  - Estrogens/deficiency/*metabolism
MH  - Female
MH  - Humans
MH  - *Immunity
MH  - *Menopause
OTO - NOTNLM
OT  - Cytokines
OT  - Immune senescence
OT  - Inflammatory molecules
OT  - Menopause
OT  - Sex steroids
EDAT- 2014/05/24 06:00
MHDA- 2015/01/28 06:00
CRDT- 2014/05/24 06:00
PHST- 2014/04/10 00:00 [received]
PHST- 2014/04/17 00:00 [revised]
PHST- 2014/04/18 00:00 [accepted]
PHST- 2014/05/24 06:00 [entrez]
PHST- 2014/05/24 06:00 [pubmed]
PHST- 2015/01/28 06:00 [medline]
AID - S0378-5122(14)00133-9 [pii]
AID - 10.1016/j.maturitas.2014.04.014 [doi]
PST - ppublish
SO  - Maturitas. 2014 Jul;78(3):174-8. doi: 10.1016/j.maturitas.2014.04.014. Epub 2014 
      May 1.