PMID- 24852565
OWN - NLM
STAT- MEDLINE
DCOM- 20140912
LR  - 20220318
IS  - 1522-1547 (Electronic)
IS  - 0193-1857 (Print)
IS  - 0193-1857 (Linking)
VI  - 307
IP  - 2
DP  - 2014 Jul 15
TI  - Flow time through esophagogastric junction derived during high-resolution 
      impedance-manometry studies: a novel parameter for assessing esophageal bolus 
      transit.
PG  - G158-63
LID - 10.1152/ajpgi.00119.2014 [doi]
AB  - This study aimed to develop and validate a method to measure bolus flow time 
      (BFT) through the esophagogastric junction (EGJ) using a high-resolution 
      impedance-manometry (HRIM) sleeve. Ten healthy subjects were studied with 
      concurrent HRIM and videofluoroscopy; another 15 controls were studied with HRIM 
      alone. HRIM studies were performed using a 4.2-mm-outer diameter assembly with 36 
      pressure sensors at 1-cm intervals and 18 impedance segments at 2-cm intervals 
      (Given Imaging, Los Angeles, CA). HRIM and fluoroscopic data from four barium 
      swallows, two in the supine and two in the upright position, were analyzed to 
      create a customized MATLAB program to calculate BFT using a HRIM sleeve 
      comprising three sensors positioned at the crural diaphragm. Bolus transit 
      through the EGJ measured during blinded review of fluoroscopy was almost 
      identical to BFT calculated with the HRIM sleeve, with the nadir impedance 
      deflection point used as the signature of bolus presence. Good correlation 
      existed between videofluoroscopy for measurement of upper sphincter relaxation to 
      beginning of flow [R = 0.97, P < 0.001 (supine) and R = 0.77, P < 0.01 (upright)] 
      and time to end of flow [R = 0.95, P < 0.001 (supine) and R = 0.82, P < 0.01 
      (upright)]. The medians and interquartile ranges (IQR) of flow time though the 
      EGJ in 15 healthy subjects calculated using the virtual sleeve were 3.5 s (IQR 
      2.3-3.9 s) in the supine position and 3.2 s (IQR 2.3-3.6 s) in the upright 
      position. BFT is a new metric that provides important information about bolus 
      transit through the EGJ. An assessment of BFT will determine when the EGJ is open 
      and will also provide a useful method to accurately assess trans-EGJ pressure 
      gradients during flow.
CI  - Copyright (c) 2014 the American Physiological Society.
FAU - Lin, Zhiyue
AU  - Lin Z
AD  - Department of Medicine, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois;
FAU - Imam, Hala
AU  - Imam H
AD  - Gastroenterology and Hepatology Unit, Department of Internal Medicine, Assiut 
      University Hospital, Assiut, Egypt.
FAU - Nicodeme, Frederic
AU  - Nicodeme F
AD  - Department of Thoracic Surgery, Centre Hospitalier de l'Universite de Montreal, 
      Montreal, Quebec, Canada; and.
FAU - Carlson, Dustin A
AU  - Carlson DA
AD  - Department of Medicine, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois;
FAU - Lin, Chen-Yuan
AU  - Lin CY
AD  - Department of Medicine, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois;
FAU - Yim, Brandon
AU  - Yim B
AD  - Department of Medicine, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois;
FAU - Kahrilas, Peter J
AU  - Kahrilas PJ
AD  - Department of Medicine, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois;
FAU - Pandolfino, John E
AU  - Pandolfino JE
AD  - Department of Medicine, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois; j-pandolfino@northwestern.edu.
LA  - eng
GR  - R01 DK056033/DK/NIDDK NIH HHS/United States
GR  - R01 DK079902/DK/NIDDK NIH HHS/United States
GR  - R01 DK-56033/DK/NIDDK NIH HHS/United States
GR  - R01 DK-079902/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Validation Study
DEP - 20140522
PL  - United States
TA  - Am J Physiol Gastrointest Liver Physiol
JT  - American journal of physiology. Gastrointestinal and liver physiology
JID - 100901227
RN  - 0 (Contrast Media)
RN  - 25BB7EKE2E (Barium Sulfate)
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Barium Sulfate
MH  - Contrast Media
MH  - Deglutition
MH  - Electric Impedance
MH  - Equipment Design
MH  - Esophageal Sphincter, Upper/physiology
MH  - Esophagogastric Junction/diagnostic imaging/*physiology
MH  - Female
MH  - Fluoroscopy
MH  - *Gastrointestinal Transit
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Manometry/instrumentation/*methods
MH  - Middle Aged
MH  - Patient Positioning
MH  - Predictive Value of Tests
MH  - Pressure
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Reproducibility of Results
MH  - Rheology
MH  - Supine Position
MH  - Time Factors
MH  - Transducers, Pressure
MH  - Video Recording
MH  - Young Adult
PMC - PMC4101677
OTO - NOTNLM
OT  - bolus transit
OT  - impedance
OT  - manometry
EDAT- 2014/05/24 06:00
MHDA- 2014/09/13 06:00
PMCR- 2015/07/15
CRDT- 2014/05/24 06:00
PHST- 2014/05/24 06:00 [entrez]
PHST- 2014/05/24 06:00 [pubmed]
PHST- 2014/09/13 06:00 [medline]
PHST- 2015/07/15 00:00 [pmc-release]
AID - ajpgi.00119.2014 [pii]
AID - GI-00119-2014 [pii]
AID - 10.1152/ajpgi.00119.2014 [doi]
PST - ppublish
SO  - Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G158-63. doi: 
      10.1152/ajpgi.00119.2014. Epub 2014 May 22.