PMID- 24852600 OWN - NLM STAT- MEDLINE DCOM- 20141224 LR - 20220321 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 11 IP - 5 DP - 2014 May 20 TI - Elevated white blood cell count is associated with higher risk of glucose metabolism disorders in middle-aged and elderly Chinese people. PG - 5497-509 LID - 10.3390/ijerph110505497 [doi] AB - White blood cell (WBC) count has been associated with diabetic risk, but whether the correlation is independent of other risk factors has hardly been studied. Moreover, very few such studies with large sample sizes have been conducted in Chinese. Therefore, we investigated the relationship between WBC count and glucose metabolism in China. We also examined the relevant variables of WBC count. A total of 9,697 subjects (mean age, 58.0 +/- 9.1 years) were recruited. The subjects were classified into four groups, including subjects with normal glucose tolerance, isolated impaired fasting glucose, impaired glucose tolerance and type 2 diabetes mellitus (T2DM). We found that WBC count increased as glucose metabolism disorders exacerbated. WBC count was also positively correlated with waist hip ratio, body mass index, smoking, triglycerides, glycosylated haemoglobin A1c (HbA1c) and 2-h postprandial glucose. In addition, high density lipoprotein and the female gender were inversely correlated with WBC levels. In patients with previously diagnosed T2DM, the course of T2DM was not correlated with WBC count. Our findings indicate that elevated WBC count is independently associated with worsening of glucose metabolism in middle-aged and elderly Chinese. In addition, loss of weight, smoking cessation, lipid-modifying therapies, and control of postprandial plasma glucose and HbA1c may ameliorate the chronic low-grade inflammation. FAU - Jiang, Hua AU - Jiang H AD - Department of Endocrinology, Chinese People's Liberation Army (PLA) General Hospital, 28 Fuxing Road, Beijing 100853, China. nndwmnby@gmail.com. FAU - Yan, Wen-Hua AU - Yan WH AD - Department of Endocrinology, Chinese People's Liberation Army (PLA) General Hospital, 28 Fuxing Road, Beijing 100853, China. yanwenhua301@163.com. FAU - Li, Chan-Juan AU - Li CJ AD - Department of Health Statistics, Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China. lichanjuan@fmmu.edu.cn. FAU - Wang, An-Ping AU - Wang AP AD - Department of Endocrinology, Chinese People's Liberation Army (PLA) General Hospital, 28 Fuxing Road, Beijing 100853, China. anping1128@hotmail.com. FAU - Dou, Jing-Tao AU - Dou JT AD - Department of Endocrinology, Chinese People's Liberation Army (PLA) General Hospital, 28 Fuxing Road, Beijing 100853, China. jingtaodou@sohu.com. FAU - Mu, Yi-Ming AU - Mu YM AD - Department of Endocrinology, Chinese People's Liberation Army (PLA) General Hospital, 28 Fuxing Road, Beijing 100853, China. muyiming@301hospital.com.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140520 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 RN - 0 (Blood Glucose) SB - IM MH - Age Factors MH - Aged MH - Blood Glucose/*metabolism MH - China/epidemiology MH - Diabetes Mellitus, Type 2/diagnosis/epidemiology MH - Female MH - Glucose Metabolism Disorders/*diagnosis/*epidemiology MH - Humans MH - *Leukocyte Count MH - Male MH - Middle Aged MH - Obesity/diagnosis/epidemiology MH - Risk Factors PMC - PMC4053882 EDAT- 2014/05/24 06:00 MHDA- 2014/12/30 06:00 PMCR- 2014/05/01 CRDT- 2014/05/24 06:00 PHST- 2014/04/04 00:00 [received] PHST- 2014/05/12 00:00 [revised] PHST- 2014/05/13 00:00 [accepted] PHST- 2014/05/24 06:00 [entrez] PHST- 2014/05/24 06:00 [pubmed] PHST- 2014/12/30 06:00 [medline] PHST- 2014/05/01 00:00 [pmc-release] AID - ijerph110505497 [pii] AID - ijerph-11-05497 [pii] AID - 10.3390/ijerph110505497 [doi] PST - epublish SO - Int J Environ Res Public Health. 2014 May 20;11(5):5497-509. doi: 10.3390/ijerph110505497.