PMID- 24853461
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20181202
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 471
IP  - 1-2
DP  - 2014 Aug 25
TI  - Incorporation of cisplatin into PEG-wrapped ultrapurified large-inner-diameter 
      MWCNTs for enhanced loading efficiency and release profile.
PG  - 157-65
LID - S0378-5173(14)00362-7 [pii]
LID - 10.1016/j.ijpharm.2014.05.022 [doi]
AB  - The efficacy of carbon nanotubes based drug delivery systems (DDSs) has long been 
      compromised by low drug loading efficiency and rapid release profile, especially 
      for drugs encapsulated inside nanotubes. To address these deficiencies, the 
      large-inner-diameter multi-walled carbon nanotubes (LID-MWCNTs) were employed to 
      synthesize an innovative cisplatin (CDDP)-loaded DDS. A multi-step purification 
      and oxidation procedure was developed to achieve ultrapurified oxidized 
      LID-MWCNTs prior to entrapping CDDP. High molecular weight polyethylene glycol 
      (PEG) was grafted onto the nanotubes to partially block the exit paths of drugs. 
      As assessed by TGA and ICP-OES analyses, CDDP loading efficiency of resulting DDS 
      was as high as 100.12%, and sustained release profile was obtained. Finally, the 
      anticancer activity on CAL-27 cells was evaluated, and enhanced inhibition effect 
      (IC50 values 3.93 mug/ml) was recorded. The successful inner-cavity-loading of 
      LID-MWCNTs also provides a basis for establishing more complicated 
      multi-functional DDSs.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Sui, Lei
AU  - Sui L
AD  - School of Stomatology, Tianjin Medical University, China No.12, Qixiangtai Rd. 
      Heping District, Tianjin 610041, China. Electronic address: suilei@tmu.edu.cn.
FAU - Yang, Tao
AU  - Yang T
AD  - School of Stomatology, Tianjin Medical University, China No.12, Qixiangtai Rd. 
      Heping District, Tianjin 610041, China. Electronic address: 
      ytdentist@outlook.com.
FAU - Gao, Ping
AU  - Gao P
AD  - School of Stomatology, Tianjin Medical University, China No.12, Qixiangtai Rd. 
      Heping District, Tianjin 610041, China.
FAU - Meng, Ai
AU  - Meng A
AD  - School of Stomatology, Tianjin Medical University, China No.12, Qixiangtai Rd. 
      Heping District, Tianjin 610041, China.
FAU - Wang, Pingting
AU  - Wang P
AD  - School of Stomatology, Tianjin Medical University, China No.12, Qixiangtai Rd. 
      Heping District, Tianjin 610041, China.
FAU - Wu, Zhenzhen
AU  - Wu Z
AD  - School of Stomatology, Tianjin Medical University, China No.12, Qixiangtai Rd. 
      Heping District, Tianjin 610041, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Prosthodontics, West China Hospital of Stomatology, Sichuan 
      University, China No.14, 3rd Section of Ren Min Nan Rd., Chengdu, Sichuan 610041, 
      China. Electronic address: ferowang@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140520
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Nanotubes, Carbon)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*administration & dosage/chemistry/pharmacology
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Cisplatin/*administration & dosage/chemistry/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Carriers/*chemistry
MH  - Drug Compounding
MH  - Drug Liberation
MH  - Fibroblasts/drug effects
MH  - Humans
MH  - Mice
MH  - Microscopy, Electron, Scanning
MH  - Nanotubes, Carbon/*chemistry
MH  - Oxidation-Reduction
MH  - Particle Size
MH  - Polyethylene Glycols/*chemistry
MH  - Surface Properties
OTO - NOTNLM
OT  - Carbon nanotubes
OT  - Cisplatin
OT  - Cytotoxicity
OT  - Drug delivery system
OT  - Drug loading efficiency
OT  - Release profile
EDAT- 2014/05/24 06:00
MHDA- 2015/02/20 06:00
CRDT- 2014/05/24 06:00
PHST- 2014/01/27 00:00 [received]
PHST- 2014/05/09 00:00 [revised]
PHST- 2014/05/16 00:00 [accepted]
PHST- 2014/05/24 06:00 [entrez]
PHST- 2014/05/24 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
AID - S0378-5173(14)00362-7 [pii]
AID - 10.1016/j.ijpharm.2014.05.022 [doi]
PST - ppublish
SO  - Int J Pharm. 2014 Aug 25;471(1-2):157-65. doi: 10.1016/j.ijpharm.2014.05.022. 
      Epub 2014 May 20.