PMID- 24854064
OWN - NLM
STAT- MEDLINE
DCOM- 20150331
LR  - 20140802
IS  - 1528-8447 (Electronic)
IS  - 1526-5900 (Linking)
VI  - 15
IP  - 8
DP  - 2014 Aug
TI  - Forced treadmill running suppresses postincisional pain and inhibits upregulation 
      of substance P and cytokines in rat dorsal root ganglion.
PG  - 827-34
LID - S1526-5900(14)00722-6 [pii]
LID - 10.1016/j.jpain.2014.04.010 [doi]
AB  - Exercise causes a variety of psychophysical effects (eg, alterations in pain 
      sensation). Tissue injury induces mediator releases in the spinal cord resulting 
      in pain hypersensitivity; however, the contribution of the dorsal root ganglion 
      (DRG) is poorly understood. In this study, we tested if forced treadmill running 
      can attenuate postoperative pain and alter substance P (SP) or proinflammatory 
      cytokine level in the DRG by using a rat model of skin/muscle incision and 
      retraction (SMIR). We evaluated mechanical sensitivity to von Frey stimuli (6 and 
      15 g) and expression of SP, interleukin-1beta, and interleukin-6 in the DRG of 
      sham-operated sedentary rats, SMIR sedentary rats, sham-operated rats with forced 
      treadmill running, and SMIR rats with forced treadmill running. At postoperative 
      day 8, trained rats ran for 5 days per week for 4 weeks on a treadmill 70 
      minutes/d with an intensity of 18 m/min. On postoperative day 6, SMIR sedentary 
      rats displayed a significant mechanical hypersensitivity that persisted until 
      postoperative day 35. By comparison, SMIR-operated rats, which received forced 
      treadmill running, exhibited a quick recovery from mechanical hypersensitivity. 
      SMIR sedentary rats showed an upregulation of SP, interleukin-1beta, and 
      interleukin-6 in the DRG at postoperative days 14 and 28, whereas SMIR-operated 
      rats receiving forced treadmill running reversed this upregulation at 
      postoperative day 28. We concluded that forced treadmill running alleviated 
      persistent postincisional pain caused by SMIR surgery. This appears to be 
      protective against postoperative pain, which probably relates to the downturn in 
      excess SP, interleukin-1beta, and interleukin-6 in the DRG. PERSPECTIVE: Controlling 
      the expression of SP, interleukin-6, and interleukin-1beta in the DRG can help 
      manage postoperative pain. This finding could potentially help clinicians and 
      physical therapists who seek to examine how exercise may attenuate postsurgical 
      pain and its mechanism.
CI  - Copyright (c) 2014 American Pain Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Chen, Yu-Wen
AU  - Chen YW
AD  - Department of Physical Therapy, Graduate Institute of Rehabilitation Science, 
      China Medical University, Taichung, Taiwan; Department of Medical Research, 
      Chi-Mei Medical Center, Yongkang, Tainan City, Taiwan.
FAU - Tzeng, Jann-Inn
AU  - Tzeng JI
AD  - Department of Food Sciences and Technology, Chia Nan University of Pharmacy and 
      Science, Tainan City, Taiwan; Department of Anesthesiology, Chi-Mei Medical 
      Center, Yongkang, Tainan City, Taiwan.
FAU - Lin, Min-Fei
AU  - Lin MF
AD  - Institute & Department of Physical Therapy, National Cheng Kung University, 
      Tainan City, Taiwan.
FAU - Hung, Ching-Hsia
AU  - Hung CH
AD  - Institute & Department of Physical Therapy, National Cheng Kung University, 
      Tainan City, Taiwan. Electronic address: chhung@mail.ncku.edu.tw.
FAU - Wang, Jhi-Joung
AU  - Wang JJ
AD  - Department of Medical Research, Chi-Mei Medical Center, Yongkang, Tainan City, 
      Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140520
PL  - United States
TA  - J Pain
JT  - The journal of pain
JID - 100898657
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 33507-63-0 (Substance P)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Cytokines/*metabolism
MH  - Disease Models, Animal
MH  - Exercise Test
MH  - Ganglia, Spinal/*metabolism
MH  - Gene Expression Regulation/*physiology
MH  - Hyperalgesia
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Pain Measurement
MH  - Pain Threshold/physiology
MH  - *Pain, Postoperative/metabolism/pathology/rehabilitation
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Substance P/*metabolism
MH  - Time Factors
OTO - NOTNLM
OT  - Skin/muscle incision and retraction
OT  - forced treadmill running
OT  - interleukin-1beta
OT  - interleukin-6
OT  - mechanical hypersensitivity
OT  - substance P
EDAT- 2014/05/24 06:00
MHDA- 2015/04/01 06:00
CRDT- 2014/05/24 06:00
PHST- 2013/08/12 00:00 [received]
PHST- 2014/04/07 00:00 [revised]
PHST- 2014/04/07 00:00 [accepted]
PHST- 2014/05/24 06:00 [entrez]
PHST- 2014/05/24 06:00 [pubmed]
PHST- 2015/04/01 06:00 [medline]
AID - S1526-5900(14)00722-6 [pii]
AID - 10.1016/j.jpain.2014.04.010 [doi]
PST - ppublish
SO  - J Pain. 2014 Aug;15(8):827-34. doi: 10.1016/j.jpain.2014.04.010. Epub 2014 May 
      20.