PMID- 24854539
OWN - NLM
STAT- MEDLINE
DCOM- 20150602
LR  - 20220318
IS  - 1437-4315 (Electronic)
IS  - 1431-6730 (Linking)
VI  - 395
IP  - 9
DP  - 2014 Sep
TI  - Low mRNA expression levels of kallikrein-related peptidase 4 (KLK4) predict 
      short-term relapse in patients with laryngeal squamous cell carcinoma.
PG  - 1051-62
LID - 10.1515/hsz-2014-0139 [doi]
AB  - Several members of the family of tissue kallikrein and kallikrein-related 
      peptidases have been suggested as promising tumor biomarkers with important 
      prognostic significance. However, only one (KLK11) has already been studied in 
      laryngeal squamous cell carcinoma (LSCC) as a potential biomarker for LSCC 
      diagnosis and/or prognosis. Our study investigated the prognostic value of 
      kallikrein-related peptidase-4 (KLK4) mRNA expression as a molecular tissue 
      biomarker in LSCC. For this purpose, KLK4 mRNA expression analysis was performed 
      in 116 cancerous and 74 paired non-cancerous laryngeal tissue specimens obtained 
      from patients that had undergone surgical treatment for primary LSCC. A 
      remarkable downregulation of KLK4 mRNA expression was discovered in laryngeal 
      tumors, compared to non-cancerous laryngeal tissue specimens. KLK4 mRNA 
      expression was also shown to distinguish LSCC from non-cancerous laryngeal 
      tissues. Furthermore, low KLK4 mRNA expression was shown to predict poor 
      disease-free survival, independently of the histological grade and size of the 
      malignant tumor as well as patient TNM stage. According to Kaplan-Meier survival 
      analysis, low KLK4 mRNA expression predicts short-term relapse even among 
      patients with well-differentiated tumors or those at an early TNM stage. Thus, 
      KLK4 mRNA positivity could be regarded as a novel independent indicator of 
      favorable prognosis for the disease-free survival of LSCC patients.
FAU - Foteinou, Emmanouela
AU  - Foteinou E
FAU - Kontos, Christos K
AU  - Kontos CK
FAU - Giotakis, Aris I
AU  - Giotakis AI
FAU - Scorilas, Andreas
AU  - Scorilas A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Biol Chem
JT  - Biological chemistry
JID - 9700112
RN  - 0 (RNA, Messenger)
RN  - EC 3.4.21.- (Kallikreins)
RN  - EC 3.4.21.- (kallikrein 4)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Cell Line, Tumor
MH  - Disease-Free Survival
MH  - Down-Regulation/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Kallikreins/*genetics/metabolism
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Larynx/metabolism/pathology
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Recurrence, Local/*genetics/pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - RNA, Messenger/genetics/metabolism
MH  - ROC Curve
EDAT- 2014/05/24 06:00
MHDA- 2015/06/03 06:00
CRDT- 2014/05/24 06:00
PHST- 2014/02/15 00:00 [received]
PHST- 2014/04/08 00:00 [accepted]
PHST- 2014/05/24 06:00 [entrez]
PHST- 2014/05/24 06:00 [pubmed]
PHST- 2015/06/03 06:00 [medline]
AID - /j/bchm.just-accepted/hsz-2014-0139/hsz-2014-0139.xml [pii]
AID - 10.1515/hsz-2014-0139 [doi]
PST - ppublish
SO  - Biol Chem. 2014 Sep;395(9):1051-62. doi: 10.1515/hsz-2014-0139.