PMID- 24855344
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140523
LR  - 20220409
IS  - 1177-889X (Print)
IS  - 1177-889X (Electronic)
IS  - 1177-889X (Linking)
VI  - 8
DP  - 2014
TI  - Impact of hypoglycemia on patients with type 2 diabetes mellitus and their 
      quality of life, work productivity, and medication adherence.
PG  - 683-92
LID - 10.2147/PPA.S58813 [doi]
AB  - BACKGROUND: The purpose of this study was to determine the characteristics of 
      adults with type 2 diabetes mellitus (T2DM) that correlate with greater risk of 
      hypoglycemia and determine the impact of hypoglycemia on health-related quality 
      of life, work productivity, and medication adherence from a patient perspective. 
      METHODS: Data from a large web-based survey were retrospectively analyzed. Adults 
      with a diagnosis of T2DM taking antihyperglycemic agents were included in the 
      analysis. Participants with knowledge of their hypoglycemic history were divided 
      into three groups: those experiencing recent hypoglycemia (previous 3 months), 
      those experiencing nonrecent hypoglycemia, and those never experiencing 
      hypoglycemia. RESULTS: Of the participants with T2DM taking antihyperglycemic 
      agents who were knowledgeable of their hypoglycemia history, 55.7% had ever 
      experienced hypoglycemia. Of those, 52.7% had recent hypoglycemia. Compared with 
      those who never experienced hypoglycemia, those who experienced hypoglycemia 
      tended to: be younger; be more aware of their glycated hemoglobin (HbA1c) levels; 
      have higher HbA1c levels; have a higher body mass index; have higher Charlson 
      Comorbidity Index scores; be on insulin, sulfonylureas, and/or glucagon-like 
      peptide-1 agonists; and be less adherent to their antihyperglycemic agents. 
      Hypoglycemia interfered with social activities, caused more missed work 
      (absenteeism), more impairment while at work (presenteeism), and decreased 
      overall work productivity compared with patients who had never experienced 
      hypoglycemia. Overall health-related quality of life, as determined by the Short 
      Form-36 health questionnaire, was negatively impacted by hypoglycemia. Both 
      Physical and Mental Summary scores were significantly lower for the recent 
      hypoglycemia and nonrecent hypoglycemia groups compared with the never 
      hypoglycemia group. CONCLUSION: Hypoglycemia can negatively impact many aspects 
      of life. Greater awareness of those who are at risk for developing hypoglycemia 
      can lead to the development of measures (eg, patient and physician education) to 
      prevent future hypoglycemia episodes.
FAU - Lopez, Janice Ms
AU  - Lopez JM
AD  - Janssen Scientific Affairs, LLC, Raritan, NJ, USA.
FAU - Annunziata, Kathy
AU  - Annunziata K
AD  - Kantar Health, Princeton, NJ, USA.
FAU - Bailey, Robert A
AU  - Bailey RA
AD  - Janssen Scientific Affairs, LLC, Raritan, NJ, USA.
FAU - Rupnow, Marcia Ft
AU  - Rupnow MF
AD  - Janssen Scientific Affairs, LLC, Raritan, NJ, USA.
FAU - Morisky, Donald E
AU  - Morisky DE
AD  - University of California at Los Angeles Fielding School of Public Health, Los 
      Angeles, CA, USA.
LA  - eng
PT  - Journal Article
DEP - 20140508
PL  - New Zealand
TA  - Patient Prefer Adherence
JT  - Patient preference and adherence
JID - 101475748
PMC - PMC4020884
OTO - NOTNLM
OT  - adherence
OT  - antihyperglycemic
OT  - burden
OT  - hemoglobin A1C
OT  - low glucose effect
OT  - patient preference
OT  - survey
EDAT- 2014/05/24 06:00
MHDA- 2014/05/24 06:01
PMCR- 2014/05/08
CRDT- 2014/05/24 06:00
PHST- 2014/05/24 06:00 [entrez]
PHST- 2014/05/24 06:00 [pubmed]
PHST- 2014/05/24 06:01 [medline]
PHST- 2014/05/08 00:00 [pmc-release]
AID - ppa-8-683 [pii]
AID - 10.2147/PPA.S58813 [doi]
PST - epublish
SO  - Patient Prefer Adherence. 2014 May 8;8:683-92. doi: 10.2147/PPA.S58813. 
      eCollection 2014.