PMID- 24855526
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140523
LR  - 20211021
IS  - 2005-3606 (Print)
IS  - 2005-5447 (Electronic)
IS  - 2005-3606 (Linking)
VI  - 2
IP  - 2
DP  - 2009 May
TI  - Usefulness of umbilical cord blood cells in era of hematopoiesis research.
PG  - 90-6
AB  - Although worldwide experience with umbilical cord blood (UCB) transplantation is 
      still relatively limited, clinical experience with UCB transplantation is 
      encouraging. The use of UCB for hematopoietic stem cell transplantation (HSCT) 
      has advantages and disadvantages. Among the advantages are rapid availability, 
      ability to more rapidly schedule the transplant as the UCB units are stored and 
      ready for use, the apparent reduced need for an exact human leukocyte antigen 
      (HLA) match, and induction of a less severe graft versus host disease (GVHD) 
      compared with bone marrow. The major limitation of reduced numbers of 
      hematopoietic stem cells (HSC) in UCB is being addressed by basic research. It is 
      promising that potential improvements in engraftment efficiency without increased 
      stem cell numbers or actual increased stem cell numbers through dual UCB 
      transplant or ex-vivo expansion might lead to improved treatment approaches. 
      However, its therapeutic potential extends beyond the hematopoietic component 
      suggesting regenerative potential in solid organs as well. Many different stem 
      and progenitor cell populations have been postulated with potential ranging from 
      embryonic like to lineage-committed progenitor cells. UCB derived MSCs have the 
      differentiation capacity and also the therapeutic potential with regard to 
      regenerative medicine, stromal support, immune modulation and gene therapy. 
      Therefore, further advances are eagerly anticipated.
FAU - Park, Seong-Kyu
AU  - Park SK
AD  - Department of Internal Medicine, Soonchunhyang University College of Medicine, 
      Seoul, Korea.
FAU - Won, Jong-Ho
AU  - Won JH
AD  - Department of Internal Medicine, Soonchunhyang University College of Medicine, 
      Seoul, Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Int J Stem Cells
JT  - International journal of stem cells
JID - 101497587
PMC - PMC4021762
OTO - NOTNLM
OT  - Therapeutic potential
OT  - Transplantation
OT  - Umbilical cord blood cells
EDAT- 2009/05/01 00:00
MHDA- 2009/05/01 00:01
PMCR- 2009/12/01
CRDT- 2014/05/24 06:00
PHST- 2009/10/19 00:00 [accepted]
PHST- 2014/05/24 06:00 [entrez]
PHST- 2009/05/01 00:00 [pubmed]
PHST- 2009/05/01 00:01 [medline]
PHST- 2009/12/01 00:00 [pmc-release]
AID - ijsc-02-090 [pii]
AID - 10.15283/ijsc.2009.2.2.90 [doi]
PST - ppublish
SO  - Int J Stem Cells. 2009 May;2(2):90-6. doi: 10.15283/ijsc.2009.2.2.90.