PMID- 24856224
OWN - NLM
STAT- MEDLINE
DCOM- 20140821
LR  - 20181202
IS  - 1527-3288 (Electronic)
IS  - 0147-9563 (Linking)
VI  - 43
IP  - 4
DP  - 2014 Jul-Aug
TI  - Increased levels of plasma CXC-Chemokine Ligand 10, 12 and 16 are associated with 
      right ventricular function in patients with idiopathic pulmonary arterial 
      hypertension.
PG  - 322-7
LID - S0147-9563(14)00124-1 [pii]
LID - 10.1016/j.hrtlng.2014.04.016 [doi]
AB  - OBJECTIVE: To investigate plasma levels of CXC-Chemokine Ligand 10 (CXCL10), 
      CXC-Chemokine Ligand 12 (CXCL12) and CXC-Chemokine Ligand 16 (CXCL16) in patients 
      with idiopathic pulmonary arterial hypertension (IPAH). METHODS: Plasma levels of 
      biomarkers were measured by enzyme-linked immunosorbent assay in 61 patients with 
      IPAH and 20 healthy volunteers. RESULTS: Plasma CXCL10, CXCL12 and CXCL16 
      concentrations were increased significantly in IPAH patients compared with 
      controls, and significantly correlated with N-terminal pro-brain natriuretic 
      peptide, tricuspid annulus plane systolic excursion and right ventricular 
      ejection fraction. CONCLUSIONS: Increased levels of CXCL10, CXCL12 and CXCL16 are 
      associated with right ventricular dysfunction in patients with IPAH.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Yang, Tao
AU  - Yang T
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
FAU - Li, Zhen-Nan
AU  - Li ZN
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
FAU - Chen, Guo
AU  - Chen G
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
FAU - Gu, Qing
AU  - Gu Q
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
FAU - Ni, Xin-Hai
AU  - Ni XH
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
FAU - Zhao, Zhi-Hui
AU  - Zhao ZH
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
FAU - Ye, Jue
AU  - Ye J
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
FAU - Meng, Xian-Min
AU  - Meng XM
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
FAU - Liu, Zhi-Hong
AU  - Liu ZH
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
FAU - Xiong, Chang-Ming
AU  - Xiong CM
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China. 
      Electronic address: xiongcm2000@163.com.
FAU - He, Jian-Guo
AU  - He JG
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China. 
      Electronic address: hejianguofw@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140522
PL  - United States
TA  - Heart Lung
JT  - Heart & lung : the journal of critical care
JID - 0330057
RN  - 0 (Biomarkers)
RN  - 0 (CXCL16 protein, human)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Chemokine CXCL16)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Receptors, Scavenger)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chemokine CXCL10/blood
MH  - Chemokine CXCL12/blood
MH  - Chemokine CXCL16
MH  - Chemokines, CXC/*blood
MH  - Familial Primary Pulmonary Hypertension
MH  - Female
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension, Pulmonary/*blood/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Receptors, Scavenger/blood
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Right/blood
MH  - Ventricular Function, Right/*physiology
OTO - NOTNLM
OT  - Biomarkers
OT  - CXC-chemokine ligand
OT  - Pulmonary arterial hypertension
OT  - Right ventricular function
EDAT- 2014/05/27 06:00
MHDA- 2014/08/22 06:00
CRDT- 2014/05/27 06:00
PHST- 2013/10/21 00:00 [received]
PHST- 2014/04/16 00:00 [revised]
PHST- 2014/04/17 00:00 [accepted]
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2014/08/22 06:00 [medline]
AID - S0147-9563(14)00124-1 [pii]
AID - 10.1016/j.hrtlng.2014.04.016 [doi]
PST - ppublish
SO  - Heart Lung. 2014 Jul-Aug;43(4):322-7. doi: 10.1016/j.hrtlng.2014.04.016. Epub 
      2014 May 22.