PMID- 24856347
OWN - NLM
STAT- MEDLINE
DCOM- 20150128
LR  - 20221207
IS  - 1872-6844 (Electronic)
IS  - 0920-1211 (Linking)
VI  - 108
IP  - 6
DP  - 2014 Aug
TI  - Genetic susceptibility to the cross-reactivity of aromatic antiepileptic 
      drugs-induced cutaneous adverse reactions.
PG  - 1041-5
LID - S0920-1211(14)00101-6 [pii]
LID - 10.1016/j.eplepsyres.2014.03.017 [doi]
AB  - BACKGROUND: The cross-allergic reactions among aromatic antiepileptic drugs 
      (AEDs) are common, but little is known about the genetic mechanisms. PURPOSE: The 
      aim of this study was to investigate the genetic associations of the human 
      leukocyte antigen (HLA) genes with the cross-reactivity of cutaneous adverse drug 
      reactions (cADRs) induced by different aromatic AEDs. METHODS: We reviewed 60 
      Chinese patients with a history of cADRs induced by an aromatic AED, and which 
      re-challenged other aromatic AEDs as an alternative to the causative AED owing to 
      some particular reasons. According to whether developing another episode of 
      cADRs, these patients were automatically divided into the cross-reactivity group 
      and tolerant control group. High-resolution HLA-A, -B, -DRB1 genotyping were 
      performed for each patient. RESULTS: One out of 10 patients (10%, 1/10) carried 
      the HLA-A*2402 allele in the cross-reactivity group. However, 23 patients (46%, 
      23/50) carried this allele in the tolerant control group. The difference of the 
      HLA-A*2402 allele between the two groups is statistically significant (P=0.040, 
      OR=0.130, 95% CI: 0.015-1.108). In addition, the frequency differences of other 
      HLA alleles between the two groups, including the HLA-B*1502 allele, did not 
      reach statistical significance (P>0.05). CONCLUSIONS: The HLA genes contribute to 
      the genetic susceptibility of the cross-reactivity of cADRs among aromatic AEDs. 
      Our results suggest that HLA-B*1502 is not a major responsible allele for the 
      cross-reactivity of cADRs to aromatic AEDs, but the HLA-A*2402 allele may be a 
      protective marker for the cross-allergic reactions among aromatic AEDs in Han 
      Chinese. Further studies are warranted to test the potential predictive value of 
      the HLA-A*2402 allele in future.
CI  - Copyright (c) 2014. Published by Elsevier B.V.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China.
FAU - Hu, Fa-Yun
AU  - Hu FY
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China.
FAU - Wu, Xin-Tong
AU  - Wu XT
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China.
FAU - An, Dong-Mei
AU  - An DM
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China.
FAU - Yan, Bo
AU  - Yan B
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China.
FAU - Zhou, Dong
AU  - Zhou D
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China. Electronic address: zhoudong66@yahoo.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140408
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
RN  - 0 (Anticonvulsants)
RN  - 0 (Biomarkers, Pharmacological)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A*24:02 antigen)
RN  - 0 (HLA-A24 Antigen)
RN  - 0 (HLA-B*15:02 antigen)
RN  - 0 (HLA-B15 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Anticonvulsants/*adverse effects
MH  - Asian People/genetics
MH  - Biomarkers, Pharmacological
MH  - Child
MH  - China
MH  - Cross Reactions/genetics
MH  - Drug Eruptions/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotyping Techniques
MH  - HLA Antigens/*genetics
MH  - HLA-A24 Antigen/genetics
MH  - HLA-B15 Antigen/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stevens-Johnson Syndrome/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Aromatic antiepileptic drugs
OT  - Cross-reactivity
OT  - Cutaneous adverse drug reactions
OT  - HLA-A*2402 allele
OT  - HLA-B*1502 allele
EDAT- 2014/05/27 06:00
MHDA- 2015/01/30 06:00
CRDT- 2014/05/27 06:00
PHST- 2013/09/03 00:00 [received]
PHST- 2014/03/01 00:00 [revised]
PHST- 2014/03/24 00:00 [accepted]
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2015/01/30 06:00 [medline]
AID - S0920-1211(14)00101-6 [pii]
AID - 10.1016/j.eplepsyres.2014.03.017 [doi]
PST - ppublish
SO  - Epilepsy Res. 2014 Aug;108(6):1041-5. doi: 10.1016/j.eplepsyres.2014.03.017. Epub 
      2014 Apr 8.