PMID- 24857853
OWN - NLM
STAT- MEDLINE
DCOM- 20151007
LR  - 20140714
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 274
DP  - 2014 Aug 22
TI  - Beneficial influence of physical exercise following status epilepticus in the 
      immature brain of rats.
PG  - 69-81
LID - S0306-4522(14)00416-3 [pii]
LID - 10.1016/j.neuroscience.2014.05.024 [doi]
AB  - Studies in adult animals have demonstrated a beneficial effect of physical 
      exercise on epileptic insults. Although the effects of physical exercise on the 
      mature nervous system are well documented, its influence on the developing 
      nervous system subjected to injuries in childhood has been little explored. The 
      purpose of our study was to investigate whether a physical exercise program 
      applied during brain development could influence the hippocampal plasticity of 
      rats submitted to status epilepticus (SE) induced by pilocarpine model at two 
      different ages of the postnatal period. Male Wistar rats aged 18 (P18) and 28 
      (P28) days were randomly divided into four groups: Control (CTRL), Exercise (EX), 
      SE (SE) and SE Exercise (SE/EX) (n=17 per group). After the aerobic exercise 
      program, histological and behavioral (water maze) analyses were performed. Our 
      results showed that only animals subjected to pilocarpine-induced SE at P28 
      presented spontaneous seizures during the observational period. A significant 
      reduction in seizure frequency was observed in the SE/EX group compared to the SE 
      group. In adulthood, animals submitted to early-life SE displayed impairment in 
      long-term memory in the water maze task, while the exercise program reversed this 
      deficit. Reduced mossy fiber sprouting in the dentate gyrus was noted in animals 
      that presented spontaneous seizures (SE/EX vs SE). Exercise increased cell 
      proliferation (Ki-67 staining) and anti-apoptotic response (bcl-2 staining) and 
      reduced pro-apoptotic response (Bax staining) in animals of both ages of SE 
      induction (P18/28). Exercise also modified the brain-derived neurotrophic factor 
      (BDNF) levels in EX and SE/EX animals. Our findings indicate that in animals 
      subjected to SE in the postnatal period a physical exercise program brings about 
      beneficial effects on seizure frequency and hippocampal plasticity in later 
      stages of life.
CI  - Copyright (c) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Gomes, F G Novaes
AU  - Gomes FG
AD  - Departamento de Fisiologia, Universidade Federal de Sao Paulo (UNIFESP), Sao 
      Paulo, SP, Brazil. Electronic address: fabiano.novaes@unifesp.br.
FAU - Gomes Da Silva, S
AU  - Gomes Da Silva S
AD  - Departamento de Fisiologia, Universidade Federal de Sao Paulo (UNIFESP), Sao 
      Paulo, SP, Brazil; Instituto do Cerebro (INCE), Instituto Israelita de Ensino e 
      Pesquisa Albert Einstein (IIEPAE), Hospital Israelita Albert Einstein, Sao Paulo, 
      SP, Brazil. Electronic address: sergio.gomes@unifesp.br.
FAU - Cavalheiro, E A
AU  - Cavalheiro EA
AD  - Disciplina de Neurologia Experimental, Universidade Federal de Sao Paulo/Escola 
      Paulista de Medicina (UNIFESP/EPM), Sao Paulo, SP, Brazil. Electronic address: 
      esper.nexp@epm.br.
FAU - Arida, R M
AU  - Arida RM
AD  - Departamento de Fisiologia, Universidade Federal de Sao Paulo (UNIFESP), Sao 
      Paulo, SP, Brazil. Electronic address: arida.nexp@epm.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140521
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 01MI4Q9DI3 (Pilocarpine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Apoptosis
MH  - Brain/metabolism/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Proliferation
MH  - *Exercise Therapy
MH  - Male
MH  - Maze Learning/physiology
MH  - Neuronal Plasticity
MH  - Pilocarpine
MH  - Rats
MH  - Rats, Wistar
MH  - Status Epilepticus/*physiopathology/*therapy
OTO - NOTNLM
OT  - brain development
OT  - epilepsy
OT  - immature brain
OT  - neuroplasticity
OT  - physical exercise
OT  - status epilepticus
EDAT- 2014/05/27 06:00
MHDA- 2015/10/08 06:00
CRDT- 2014/05/27 06:00
PHST- 2014/04/02 00:00 [received]
PHST- 2014/05/10 00:00 [revised]
PHST- 2014/05/13 00:00 [accepted]
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2015/10/08 06:00 [medline]
AID - S0306-4522(14)00416-3 [pii]
AID - 10.1016/j.neuroscience.2014.05.024 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Aug 22;274:69-81. doi: 10.1016/j.neuroscience.2014.05.024. 
      Epub 2014 May 21.