PMID- 24857867
OWN - NLM
STAT- MEDLINE
DCOM- 20150312
LR  - 20181202
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 69
DP  - 2014 Aug
TI  - Selenium-dependent antitumor immunomodulating activity of polysaccharides from 
      roots of A. membranaceus.
PG  - 64-72
LID - S0141-8130(14)00316-X [pii]
LID - 10.1016/j.ijbiomac.2014.05.020 [doi]
AB  - Roots of Astragalus membranaceus (Fish.) Bge. var. mongholicus (Bge.) Hsiao (A. 
      membranaceus) have been long used as an auxiliary reagent supporting cancer 
      treatment. Here, we compared the chemical composition and antitumor 
      immunomodulating activity of polysaccharides from roots of A. membranaceus (PAMs) 
      from five major habitats in Inner Mongolia, PR China. We revealed that 
      compositions of monosaccharides and amino acids were comparable among PAMs from 
      different habitats. However, amounts of selenium varied widely in roots of A. 
      membranaceus and PAMs. PAMs selenium-dependently repressed the in vivo 
      proliferation of transplanted H22 ascitic hepatoma and S180 sarcoma cells with 
      low toxic impacts on tumor-bearing mice. Selenium-containing PAMs ameliorated 
      host CD4+ T cell apoptosis and serum cytokine dysregulation induced by tumor 
      transplantation, leading to the enhancement of cytotoxic activities of natural 
      killer and CD8+ T cells. Moreover, PAMs also selenium-dependently improved the 
      phagocytotic function of intra-abdominal macrophages and suppressed M2-like 
      polarization of tumor-associated macrophages. These data suggested that the 
      selenium content varies in the roots of A. membranaceus and PAMs from different 
      geographical origins dramatically and selenium is an important contributor to the 
      antitumor immunomodulation activities of PAMs.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Li, Shuang
AU  - Li S
AD  - International School of Software, Wuhan University, Wuhan, PR China.
FAU - Bian, Fuling
AU  - Bian F
AD  - International School of Software, Wuhan University, Wuhan, PR China.
FAU - Yue, Ling
AU  - Yue L
AD  - Endocrinology Department, Wuhan General Hospital of Guangzhou Military Command, 
      Wuhan, PR China.
FAU - Jin, Hua
AU  - Jin H
AD  - Institute of Grassland Surveying and Planning, Inner Mongolia, PR China.
FAU - Hong, Zongguo
AU  - Hong Z
AD  - College of Pharmacy, South-Central University for Nationalities, Wuhan, PR China.
FAU - Shu, Guangwen
AU  - Shu G
AD  - College of Pharmacy, South-Central University for Nationalities, Wuhan, PR China. 
      Electronic address: shuguangwen@whu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140520
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Immunologic Factors)
RN  - 0 (Polysaccharides)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/chemistry/pharmacology/toxicity
MH  - Astragalus propinquus/*chemistry
MH  - CD4-Positive T-Lymphocytes/drug effects/immunology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Cytokines/metabolism
MH  - Homeostasis/drug effects
MH  - Immunologic Factors/chemistry/pharmacology/toxicity
MH  - Male
MH  - Mice
MH  - Plant Roots/*chemistry
MH  - Polysaccharides/*chemistry/*pharmacology/toxicity
MH  - Selenium/*chemistry
OTO - NOTNLM
OT  - Antitumor
OT  - Immunomodulation
OT  - Selenium-containing polysaccharide
EDAT- 2014/05/27 06:00
MHDA- 2015/03/13 06:00
CRDT- 2014/05/27 06:00
PHST- 2014/02/04 00:00 [received]
PHST- 2014/05/06 00:00 [revised]
PHST- 2014/05/07 00:00 [accepted]
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2015/03/13 06:00 [medline]
AID - S0141-8130(14)00316-X [pii]
AID - 10.1016/j.ijbiomac.2014.05.020 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2014 Aug;69:64-72. doi: 10.1016/j.ijbiomac.2014.05.020. Epub 
      2014 May 20.