PMID- 24857911
OWN - NLM
STAT- MEDLINE
DCOM- 20150106
LR  - 20221207
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 15
IP  - 5
DP  - 2014 May 5
TI  - Different role of tumor necrosis factor-alpha polymorphism in non-Hodgkin lymphomas 
      among Caucasian and Asian populations: a meta-analysis.
PG  - 7684-98
LID - 10.3390/ijms15057684 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an immunoregulatory cytokine involved in B- 
      and T-cell function, and also plays an important role in inflammation and cancer. 
      TNF-alpha-308G>A has been associated with constitutively elevated TNF-alpha expression. 
      Several studies have reported the association between the TNF-alpha-308G>A 
      polymorphism and non-Hodgkin lymphomas (NHL) risk, however, results are still 
      inconsistent. To solve these conflicts, we conducted the first meta-analysis to 
      assess the effect of TNF-alpha-308G>A polymorphism on the risk of NHL and various 
      subtypes (additive model) including 10,619 cases and 12,977 controls in Caucasian 
      and Asian populations. Our meta-analysis indicated that TNF-alpha-308G>A polymorphism 
      is not associated with NHL risk when pooling all studies together (OR=1.06, 95% 
      CI: 0.92-1.23, p=0.413). In stratified analyses, we found TNF-alpha-308A allele was 
      significantly associated with higher risk of NHL, B-cell lymphomas (BCL), T-cell 
      lymphomas (TCL) and diffuse large B-cell lymphomas (DLBCL) in Caucasians 
      (OR=1.22, 95% CI: 1.06-1.40, p=0.007; OR=1.18, 95% CI: 1.03-1.34, p=0.014; 
      OR=1.20, 95% CI: 1.01-1.42, p=0.040; OR=1.21, 95% CI: 1.11-1.32, p<0.001, 
      respectively). Interestingly, it was associated with decreased risk of NHL, BCL 
      and DLBCL in Asians (OR=0.75, 95% CI: 0.66-0.86, p<0.001; OR=0.70, 95% CI: 
      0.52-0.94, p=0.018; OR=0.70, 95% CI: 0.57-0.86, p=0.001). These findings also 
      suggest TNF-alpha might play a distinct role in pathogenesis of NHL in different 
      populations.
FAU - Zhai, Kan
AU  - Zhai K
AD  - Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing 100020, China. kan_zhai@sina.com.
FAU - Ding, Jie
AU  - Ding J
AD  - Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing 100020, China. ding201cy@sina.com.
FAU - Zhou, Yan
AU  - Zhou Y
AD  - Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing 100020, China. abi373a@sohu.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20140505
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Databases, Factual
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/*genetics/pathology
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - White People/*genetics
PMC - PMC4057699
EDAT- 2014/05/27 06:00
MHDA- 2015/01/07 06:00
PMCR- 2014/05/01
CRDT- 2014/05/27 06:00
PHST- 2014/03/12 00:00 [received]
PHST- 2014/04/15 00:00 [revised]
PHST- 2014/04/23 00:00 [accepted]
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2015/01/07 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - ijms15057684 [pii]
AID - ijms-15-07684 [pii]
AID - 10.3390/ijms15057684 [doi]
PST - epublish
SO  - Int J Mol Sci. 2014 May 5;15(5):7684-98. doi: 10.3390/ijms15057684.