PMID- 24858726
OWN - NLM
STAT- MEDLINE
DCOM- 20150720
LR  - 20211203
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 37
IP  - 6
DP  - 2014 Dec
TI  - The differential roles of mTOR, ERK, and JNK pathways in invariant natural killer 
      T-cell function and survival.
PG  - 2013-9
LID - 10.1007/s10753-014-9933-y [doi]
AB  - Invariant natural killer T (iNKT) cell is a critical element for both innate and 
      adaptive immunity. The quick responses of mature iNKT cells to TCR stimulation 
      require activation of several different signaling pathways. However, the roles of 
      these signaling pathways in mature iNKT cell biology remain incompletely 
      understood. To address this issue, single signaling pathway was blocked with 
      inhibitor in iNKT cells, and the roles of these signaling pathways were 
      estimated. Results showed that mammalian target of rapamycin (mTOR) plays an 
      essential role for cytokine production and survival in iNKT cells. In contrast, 
      ERK and JNK are more important for iNKT cell effector function, but not survival. 
      Our findings delineate the distinct roles of different signaling pathways in 
      mature iNKT cells and therefore shed new light for modulating iNKT cell function 
      in disease conditions.
FAU - Tian, Jun
AU  - Tian J
AD  - Yantai Stomatological Hospital, Yantai, 264001, Shandong, China, 
      jun-tian1990@hotmail.com.
FAU - Liu, Li
AU  - Liu L
FAU - Wang, Xiangai
AU  - Wang X
FAU - Sun, Xuewu
AU  - Sun X
FAU - Mu, Suli
AU  - Mu S
FAU - Wu, Chuanjun
AU  - Wu C
FAU - Han, Maoqiang
AU  - Han M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Cytokines)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Animals
MH  - Cell Survival/drug effects/physiology
MH  - Cytokines/biosynthesis
MH  - MAP Kinase Signaling System/drug effects/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Natural Killer T-Cells/drug effects/*physiology
MH  - Sirolimus/pharmacology
MH  - TOR Serine-Threonine Kinases/*physiology
EDAT- 2014/05/27 06:00
MHDA- 2015/07/21 06:00
CRDT- 2014/05/27 06:00
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2015/07/21 06:00 [medline]
AID - 10.1007/s10753-014-9933-y [doi]
PST - ppublish
SO  - Inflammation. 2014 Dec;37(6):2013-9. doi: 10.1007/s10753-014-9933-y.