PMID- 24858736
OWN - NLM
STAT- MEDLINE
DCOM- 20150723
LR  - 20220409
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 47
IP  - 3
DP  - 2014 Dec
TI  - Selenium supplementation and the risk of type 2 diabetes mellitus: a 
      meta-analysis of randomized controlled trials.
PG  - 758-63
LID - 10.1007/s12020-014-0298-7 [doi]
AB  - It is well documented that selenium (Se) is involved in the metabolism of 
      glucose. However, whether Se supplementation could lower the risk of type 2 
      diabetes mellitus (T2DM) remains elusive. We aimed to evaluate the association 
      between Se supplementation and the risk of T2DM by performing a meta-analysis. We 
      searched the Pubmed, Embase, and Cochrane databases from January 1990 to November 
      2013 to identify randomized controlled trials (RCTs) that met pre-stated 
      inclusion criteria. Reference lists of retrieved articles were also reviewed. 
      Either a fixed-effects or, in the presence of heterogeneity, a random-effects 
      model was used to calculate the pooled prevention effects. Four RCTs involving 
      20,294 participants were included in this meta-analysis. The combined relative 
      risks (RRs) for subjects administered with Se compared with control groups were 
      1.09 (95 % CI: 0.99-1.20, p = 0.085). Omission of any single study did not change 
      the overall risk estimates significantly. Meta- regression analyses showed almost 
      no impact on the RRs of age and study length. No evidence of publication bias was 
      observed. In conclusion, our findings do not support the routine application of 
      Se supplementation for T2DM prevention in Caucasians. Larger studies are needed 
      to investigate the effects of Se supplementation on T2DM prevention among various 
      populations and further elucidate the impact of age and study length.
FAU - Mao, Song
AU  - Mao S
AD  - Department of Nephrology, Nanjing Children's Hospital, Affiliated to Nanjing 
      Medical University, Nanjing, China.
FAU - Zhang, Aihua
AU  - Zhang A
FAU - Huang, Songming
AU  - Huang S
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20140525
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - H6241UJ22B (Selenium)
SB  - IM
EIN - Endocrine. 2016 May;52(2):401. PMID: 26910397
MH  - Diabetes Mellitus, Type 2/*prevention & control
MH  - *Dietary Supplements
MH  - Humans
MH  - Randomized Controlled Trials as Topic
MH  - Risk
MH  - Selenium/*administration & dosage
EDAT- 2014/05/27 06:00
MHDA- 2015/07/24 06:00
CRDT- 2014/05/27 06:00
PHST- 2014/02/06 00:00 [received]
PHST- 2014/05/09 00:00 [accepted]
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2015/07/24 06:00 [medline]
AID - 10.1007/s12020-014-0298-7 [doi]
PST - ppublish
SO  - Endocrine. 2014 Dec;47(3):758-63. doi: 10.1007/s12020-014-0298-7. Epub 2014 May 
      25.