PMID- 24858936
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1532-298X (Electronic)
IS  - 1040-4651 (Print)
IS  - 1040-4651 (Linking)
VI  - 26
IP  - 5
DP  - 2014 May
TI  - PHYTOCHROME INTERACTING FACTOR1 Enhances the E3 Ligase Activity of CONSTITUTIVE 
      PHOTOMORPHOGENIC1 to Synergistically Repress Photomorphogenesis in Arabidopsis.
PG  - 1992-2006
AB  - CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) is a RING/WD40 repeat-containing ubiquitin 
      E3 ligase that is conserved from plants to humans. COP1 forms complexes with 
      SUPPRESSOR OF PHYTOCHROME A (SPA) proteins, and these complexes degrade 
      positively acting transcription factors in the dark to repress 
      photomorphogenesis. Phytochrome-interacting basic helix-loop-helix transcription 
      factors (PIFs) also repress photomorphogenesis in the dark. In response to light, 
      the phytochrome family of sensory photoreceptors simultaneously inactivates 
      COP1-SPA complexes and induces the rapid degradation of PIFs to promote 
      photomorphogenesis. However, the functional relationship between PIFs and 
      COP1-SPA complexes is still unknown. Here, we present genetic evidence that the 
      pif and cop1/spa Arabidopsis thaliana mutants synergistically promote 
      photomorphogenesis in the dark. LONG HYPOCOTYL5 (HY5) is stabilized in the cop1 
      pif1, spa123 pif1, and pif double, triple, and quadruple mutants in the dark. 
      Moreover, the hy5 mutant suppresses the constitutive photomorphogenic phenotypes 
      of the pifq mutant in the dark. PIF1 forms complexes with COP1, HY5, and SPA1 and 
      enhances the substrate recruitment and autoubiquitylation and transubiquitylation 
      activities of COP1. These data uncover a novel function of PIFs as the potential 
      cofactors of COP1 and provide a genetic and biochemical model of how PIFs and 
      COP1-SPA complexes synergistically repress photomorphogenesis in the dark.
CI  - (c) 2014 American Society of Plant Biologists. All rights reserved.
FAU - Xu, Xiaosa
AU  - Xu X
AD  - Department of Molecular Biosciences and Institute for Cellular and Molecular 
      Biology, University of Texas at Austin, Austin, Texas 78712.
FAU - Paik, Inyup
AU  - Paik I
AD  - Department of Molecular Biosciences and Institute for Cellular and Molecular 
      Biology, University of Texas at Austin, Austin, Texas 78712.
FAU - Zhu, Ling
AU  - Zhu L
AD  - Department of Molecular Biosciences and Institute for Cellular and Molecular 
      Biology, University of Texas at Austin, Austin, Texas 78712.
FAU - Bu, Qingyun
AU  - Bu Q
AD  - Department of Molecular Biosciences and Institute for Cellular and Molecular 
      Biology, University of Texas at Austin, Austin, Texas 78712.
FAU - Huang, Xi
AU  - Huang X
AD  - Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, 
      State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, College of Life Sciences, Peking University, Beijing 100871, 
      China Department of Molecular, Cellular, and Developmental Biology, Yale 
      University, New Haven, Connecticut 06520.
FAU - Deng, Xing Wang
AU  - Deng XW
AD  - Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, 
      State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, College of Life Sciences, Peking University, Beijing 100871, 
      China Department of Molecular, Cellular, and Developmental Biology, Yale 
      University, New Haven, Connecticut 06520.
FAU - Huq, Enamul
AU  - Huq E
AD  - Department of Molecular Biosciences and Institute for Cellular and Molecular 
      Biology, University of Texas at Austin, Austin, Texas 78712 
      huq@austin.utexas.edu.
LA  - eng
GR  - R01 GM047850/GM/NIGMS NIH HHS/United States
GR  - R37 GM047850/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20140523
PL  - England
TA  - Plant Cell
JT  - The Plant cell
JID - 9208688
PMC - PMC4079364
EDAT- 2014/05/27 06:00
MHDA- 2014/05/27 06:01
PMCR- 2015/05/01
CRDT- 2014/05/27 06:00
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2014/05/27 06:01 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - tpc.114.125591 [pii]
AID - 125591 [pii]
AID - 10.1105/tpc.114.125591 [doi]
PST - ppublish
SO  - Plant Cell. 2014 May;26(5):1992-2006. doi: 10.1105/tpc.114.125591. Epub 2014 May 
      23.