PMID- 24859292
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20180816
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 54
DP  - 2014 Oct 3
TI  - Serum brain-derived neurotrophic factor and cognitive functioning in underweight, 
      weight-recovered and partially weight-recovered females with anorexia nervosa.
PG  - 163-9
LID - S0278-5846(14)00097-9 [pii]
LID - 10.1016/j.pnpbp.2014.05.006 [doi]
AB  - Several studies support the assumption that the brain-derived neurotrophic factor 
      (BDNF) plays an important role in the pathophysiology of eating disorders. In the 
      present cross-sectional and longitudinal study, we investigated BDNF levels in 
      patients with anorexia nervosa (AN) at different stages of their illness and the 
      association with cognitive functioning. We measured serum BDNF in 72 acutely 
      underweight female AN patients (acAN), 23 female AN patients who successfully 
      recovered from their illness (recAN), and 52 healthy control women (HCW). 
      Longitudinally, 30 acAN patients were reassessed after short-term weight gain. 
      The association between BDNF levels and psychomotor speed was investigated using 
      the Trail Making Test. BDNF serum concentrations were significantly higher in 
      recAN participants if compared to acAN patients and increased with short-term 
      weight gain. In acAN patients, but not HCW, BDNF levels were inversely associated 
      with psychomotor speed. AcAN patients with higher BDNF levels also had lower life 
      time body mass indexes. Taken together, our results indicate that serum BDNF 
      levels in patients with AN vary with the stage of illness. Based on the 
      pleiotropic functions of BDNF, changing levels of this neurotrophin may have 
      different context-dependent effects, one of which may be the modulation of 
      cognitive functioning in acutely underweight patients.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Zwipp, Johannes
AU  - Zwipp J
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany.
FAU - Hass, Johanna
AU  - Hass J
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany.
FAU - Schober, Ilka
AU  - Schober I
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany.
FAU - Geisler, Daniel
AU  - Geisler D
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany.
FAU - Ritschel, Franziska
AU  - Ritschel F
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany.
FAU - Seidel, Maria
AU  - Seidel M
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany.
FAU - Weiss, Jessika
AU  - Weiss J
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany.
FAU - Roessner, Veit
AU  - Roessner V
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany.
FAU - Hellweg, Rainer
AU  - Hellweg R
AD  - Department of Psychiatry and Psychotherapy, Charite-Universitatsmedizin Berlin, 
      Berlin, Germany.
FAU - Ehrlich, Stefan
AU  - Ehrlich S
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany; MGH/MIT/HMS Martinos 
      Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 
      USA; Harvard Medical School, Department of Psychiatry, Massachusetts General 
      Hospital, Boston, MA, USA. Electronic address: transden.lab@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20140522
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Anorexia Nervosa/*blood/*psychology
MH  - Body Mass Index
MH  - Body Weight/physiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition/*physiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Neuropsychological Tests
MH  - Psychomotor Performance/physiology
MH  - Thinness/blood/psychology
MH  - Weight Gain/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Anorexia nervosa
OT  - BDNF
OT  - Cognitive functioning
OT  - Longitudinal
OT  - Weight gain
EDAT- 2014/05/27 06:00
MHDA- 2015/05/13 06:00
CRDT- 2014/05/27 06:00
PHST- 2014/02/26 00:00 [received]
PHST- 2014/05/06 00:00 [revised]
PHST- 2014/05/12 00:00 [accepted]
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
AID - S0278-5846(14)00097-9 [pii]
AID - 10.1016/j.pnpbp.2014.05.006 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:163-9. doi: 
      10.1016/j.pnpbp.2014.05.006. Epub 2014 May 22.