PMID- 24860124 OWN - NLM STAT- MEDLINE DCOM- 20151116 LR - 20150225 IS - 1477-111X (Electronic) IS - 0267-6591 (Linking) VI - 30 IP - 2 DP - 2015 Mar TI - Evidence-based use of FFP: the influence of a priming strategy without FFP during CPB on postoperative coagulation and recovery in pediatric patients. PG - 140-7 LID - 10.1177/0267659114537328 [doi] AB - OBJECTIVE: Although fresh frozen plasma (FFP) is one of the most commonly used hemostatic agents in clinical specialties today, there is little evidence available supporting its administration. Our present study observed the effects of a priming strategy without FFP during cardiopulmonary bypass (CPB) on postoperative coagulation and clinical recovery in pediatric patients, aiming to supply new evidence for evidence-based use of FFP. METHOD: Eighty pediatric patients with congenital heart disease undergoing cardiac surgery with CPB were randomized to receive either 10-20 ml/kg 4% succinylated gelatin (Gelofusine, GEL group, n = 40) or 1-2 units FFP (FFP group, n = 40) in the pump prime. Rapid-thromboelastography (r-TEG) and functional fibrinogen level were measured before skin incision and 15 minutes after heparin reversal. We recorded the volume of chest tube drainage, transfusion requirements and the dosage of pharmacological agents. The ventilation time, ICU length of stay and hospitalization time after surgery were also collected. RESULTS: After heparin neutralization, there were significantly elevated levels of fibrinogen in the FFP group, which were manifested by r-TEG parameters MAf and FLEV. No significant differences were observed between the two groups in postoperative bleeding, transfusion requirements and the usage of pharmacological agents. Recovery time was also comparable between the two groups. CONCLUSION: In conclusion, prophylactic use of FFP in the priming solution does not provide clinical benefits as presumed. Artificial colloids, such as Gelofusine, can be used safely and effectively as a substitute for FFP in the pump prime. TEG is an effective assessment tool to evaluate postoperative coagulation function in pediatric patients. CI - (c) The Author(s) 2014. FAU - Miao, X AU - Miao X AD - Department of Cardiopulmonary Bypass, Fuwai Hospital & National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and the Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. FAU - Liu, J AU - Liu J AD - Department of Cardiopulmonary Bypass, Fuwai Hospital & National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and the Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China jinpingfw@hotmail.com. FAU - Zhao, M AU - Zhao M AD - Department of Cardiopulmonary Bypass, Fuwai Hospital & National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and the Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. FAU - Cui, Y AU - Cui Y AD - Department of Cardiopulmonary Bypass, Fuwai Hospital & National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and the Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. FAU - Feng, Z AU - Feng Z AD - Department of Cardiopulmonary Bypass, Fuwai Hospital & National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and the Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. FAU - Zhao, J AU - Zhao J AD - Department of Cardiopulmonary Bypass, Fuwai Hospital & National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and the Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. FAU - Long, C AU - Long C AD - Department of Cardiopulmonary Bypass, Fuwai Hospital & National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and the Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. FAU - Li, S AU - Li S AD - Department of Cardiac Surgery, Fuwai Hospital & National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and the Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. FAU - Yan, F AU - Yan F AD - Department of Anesthesiology, Fuwai Hospital & National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and the Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. FAU - Wang, X AU - Wang X AD - Department of Cardiac Surgery, Fuwai Hospital & National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and the Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. FAU - Hu, S AU - Hu S AD - Department of Cardiac Surgery, Fuwai Hospital & National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease and the Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20140523 PL - England TA - Perfusion JT - Perfusion JID - 8700166 RN - 0 (Succinates) RN - 39340-57-3 (succinylated gelatin) RN - 9000-70-8 (Gelatin) SB - IM MH - Blood Coagulation/*drug effects MH - *Blood Component Transfusion MH - *Cardiopulmonary Bypass MH - Evidence-Based Medicine MH - Female MH - Gelatin/*administration & dosage MH - Heart Defects, Congenital/metabolism/*surgery MH - Humans MH - Infant MH - Male MH - *Plasma MH - Postoperative Period MH - Succinates/*administration & dosage OTO - NOTNLM OT - blood conservation OT - cardiopulmonary bypass OT - coagulation OT - congenital heart disease OT - fresh frozen plasma OT - thromboelastography EDAT- 2014/05/27 06:00 MHDA- 2015/11/17 06:00 CRDT- 2014/05/27 06:00 PHST- 2014/05/27 06:00 [entrez] PHST- 2014/05/27 06:00 [pubmed] PHST- 2015/11/17 06:00 [medline] AID - 0267659114537328 [pii] AID - 10.1177/0267659114537328 [doi] PST - ppublish SO - Perfusion. 2015 Mar;30(2):140-7. doi: 10.1177/0267659114537328. Epub 2014 May 23.