PMID- 24860650
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20240502
IS  - 2051-7599 (Print)
IS  - 2051-7599 (Electronic)
IS  - 2051-7599 (Linking)
VI  - 6
DP  - 2014
TI  - Cell-mediated immunity to human CMV infection: a brief overview.
PG  - 28
LID - 10.12703/P6-28 [doi]
LID - 28
AB  - The cellular immune response to human cytomegalovirus (HCMV) has different 
      components originating from both the adaptive and innate immune systems. There is 
      a significant global interest in understanding how the immune system keeps HCMV 
      under control, in particular with a view to situations where HCMV infection 
      causes severe damage. Such settings include HIV infection, transplantation, and 
      maybe most importantly perinatal medicine, HCMV being a major cause of sometimes 
      catastrophic birth defects. The development of an active HCMV vaccine has proven 
      very difficult but some recent successes raise hope that this might be available 
      in the future. However, adoptive transfer of HCMV-specific T cells has been 
      successfully used to prevent CMV disease after bone marrow transplantation for 
      many years. In fact, the CD8 T cell response has been thought to be the most 
      important effector response, with numerous reports focusing on specific T cell 
      subsets recognizing select peptides in select human leukocyte antigen (HLA) 
      contexts. However, it is becoming increasingly clear now that other cells, first 
      and foremost CD4 T cells, but also gamma/delta (gamma/delta) T cells and natural killer 
      cells, are critically involved in the cellular immune response to HCMV. This 
      commentary aims to provide a brief overview of the field.
FAU - Terrazzini, Nadia
AU  - Terrazzini N
AD  - Pathogen Host Interaction Group (PHI), Immunology, Division of Medicine, Brighton 
      and Sussex Medical School Biology Road, Brighton, BN1 9PS UK.
FAU - Kern, Florian
AU  - Kern F
AD  - Pathogen Host Interaction Group (PHI), Immunology, Division of Medicine, Brighton 
      and Sussex Medical School Biology Road, Brighton, BN1 9PS UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140506
PL  - England
TA  - F1000Prime Rep
JT  - F1000prime reports
JID - 101599397
PMC - PMC4018181
EDAT- 2014/05/27 06:00
MHDA- 2014/05/27 06:01
PMCR- 2014/05/06
CRDT- 2014/05/27 06:00
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2014/05/27 06:01 [medline]
PHST- 2014/05/06 00:00 [pmc-release]
AID - 28 [pii]
AID - 10.12703/P6-28 [doi]
PST - epublish
SO  - F1000Prime Rep. 2014 May 6;6:28. doi: 10.12703/P6-28. eCollection 2014.