PMID- 24860665
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140526
LR  - 20211021
IS  - 2090-1852 (Print)
IS  - 2090-1860 (Electronic)
IS  - 2090-1860 (Linking)
VI  - 2014
DP  - 2014
TI  - Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant 
      Protein-1: A-2138T and A-2464G Mutation.
PG  - 176535
LID - 10.1155/2014/176535 [doi]
LID - 176535
AB  - Carotid intima media thickness (CIMT) is clearly associated with atherosclerosis. 
      Studies in ischemic stroke patients reveal that there is a significant 
      association between CIMT with monocyte chemoattractant protein-1 (MCP-1) and 
      osteopontin (OPN) promoter polymorphism. This research aims to explain the effect 
      of MCP-1 and OPN promoter polymorphism toward CIMT changes identified in Javanese 
      Indonesian children. Subjects were 54 children: 27 were from parents with 
      ischemic stroke (cases), and 27 were from healthy parents (controlled). The CIMT 
      was examined by utilizing high resolution B-mode ultrasound. Physical examination 
      and genotyping analysis of MCP-1 promoter were conducted by employing PCR method. 
      Research results indicate that two polymorphisms were obtained, that is, A-2138T 
      and G-2464A, respectively. A-2138T polymorphism was found in 5% of case children 
      and in 14.3% of controlled children. G-2464A polymorphism was found in 5% of case 
      children. CIMT of case children was significantly different from that of 
      controlled children (0.61 +/- 0.012 mm versus, 0.52 +/- 0.015 mm, P = 0.021). 
      Subjects with MCP-1 promoter polymorphism have 1.471 times higher tendency to 
      have thicker CIMT than subjects with no polymorphism in MCP1 promoter. OPN 
      promoter T-66G was also studied but it did not indicate occurrence of 
      polymorphism in samples.
FAU - Yueniwati, Yuyun
AU  - Yueniwati Y
AD  - Radiology Department, Medical Faculty, University of Brawijaya, Malang 65145, 
      Indonesia.
FAU - Yurina, Valentina
AU  - Yurina V
AD  - Pharmacy Study Program, Medical Faculty, University of Brawijaya, Malang 65145, 
      Indonesia.
FAU - Indra, Mohammad Rasjad
AU  - Indra MR
AD  - Physiology Laboratory, Medical Faculty, University of Brawijaya, Malang 65145, 
      Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20140422
PL  - United States
TA  - Neurol Res Int
JT  - Neurology research international
JID - 101543314
PMC - PMC4016921
EDAT- 2014/05/27 06:00
MHDA- 2014/05/27 06:01
PMCR- 2014/04/22
CRDT- 2014/05/27 06:00
PHST- 2014/01/13 00:00 [received]
PHST- 2014/03/12 00:00 [revised]
PHST- 2014/04/04 00:00 [accepted]
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2014/05/27 06:01 [medline]
PHST- 2014/04/22 00:00 [pmc-release]
AID - 10.1155/2014/176535 [doi]
PST - ppublish
SO  - Neurol Res Int. 2014;2014:176535. doi: 10.1155/2014/176535. Epub 2014 Apr 22.