PMID- 24860731
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2225-4110 (Print)
IS  - 2225-4110 (Electronic)
IS  - 2225-4110 (Linking)
VI  - 4
IP  - 2
DP  - 2014 Apr
TI  - Omega-3 Fatty acids could alleviate the risks of traumatic brain injury - a mini 
      review.
PG  - 89-92
LID - 10.4103/2225-4110.130374 [doi]
AB  - Traumatic brain injury (TBI) is an acquired brain trauma that occurs when any 
      sudden trauma/injury causes damage to the brain. TBI is characterized by tissue 
      damage and imbalance in the cerebral blood flow and metabolism. It has been 
      established through laboratory experiments that the dietary supplementation of 
      omega-3 fatty acids (FAs) could reduce the oxidative stress developed in brain 
      due to TBI. The inclusion of omega-3 FA in diet could normalize the levels of 
      brain-derived neurotrophic factor (BDNF), and thus, it could restore the survival 
      of neuronal cells. BDNF improves the synaptic transmission by regulating synapsin 
      1 and cyclic adenosine monophosphate (cAMP) response element binding protein. The 
      brain tissue analysis of TBI models supplemented with omega-3 polyunsaturated 
      fatty acids (PUFAs) showed significantly reduced lipid peroxidation, nucleic acid 
      and protein oxidation, thereby promoting neuronal and glial cell survival. Thus, 
      omega-3 FA intake could be considered as a therapeutic option to reduce the 
      secondary neuronal damages initiated by TBI.
FAU - Kumar, Parvathy R
AU  - Kumar PR
AD  - Department of Food Science and Nutrition, College of Agricultural and Marine 
      Sciences, Sultan Qaboos University, Sultanate of Oman. ; Ageing and Dementia 
      Research Group, Sultan Qaboos University, Sultanate of Oman.
FAU - Essa, Musthafa Mohamed
AU  - Essa MM
AD  - Department of Food Science and Nutrition, College of Agricultural and Marine 
      Sciences, Sultan Qaboos University, Sultanate of Oman. ; Ageing and Dementia 
      Research Group, Sultan Qaboos University, Sultanate of Oman.
FAU - Al-Adawi, Samir
AU  - Al-Adawi S
AD  - Ageing and Dementia Research Group, Sultan Qaboos University, Sultanate of Oman. 
      ; College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of 
      Oman.
FAU - Dradekh, Ghazi
AU  - Dradekh G
AD  - Department of Food Science and Nutrition, College of Agricultural and Marine 
      Sciences, Sultan Qaboos University, Sultanate of Oman. ; Ageing and Dementia 
      Research Group, Sultan Qaboos University, Sultanate of Oman.
FAU - Memon, Mushtaq A
AU  - Memon MA
AD  - College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
FAU - Akbar, Mohammed
AU  - Akbar M
AD  - Laboratory of Molecular Signaling, National Institute on Alcohol Abuse and 
      Alcoholism, National Institutes of Health, Rockville, MD, USA.
FAU - Manivasagam, Thamilarasan
AU  - Manivasagam T
AD  - Department of Biochemistry and Biotechnology, Annamalai University, Tamil Nadu, 
      India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Tradit Complement Med
JT  - Journal of traditional and complementary medicine
JID - 101605474
PMC - PMC4003707
OTO - NOTNLM
OT  - Brain trauma
OT  - Neuronal damage
OT  - Oman
OT  - Omega-3 fatty acids
OT  - Traumatic brain injury
EDAT- 2014/05/27 06:00
MHDA- 2014/05/27 06:01
PMCR- 2014/04/01
CRDT- 2014/05/27 06:00
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2014/05/27 06:01 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - JTCM-4-89 [pii]
AID - 10.4103/2225-4110.130374 [doi]
PST - ppublish
SO  - J Tradit Complement Med. 2014 Apr;4(2):89-92. doi: 10.4103/2225-4110.130374.