PMID- 24860833
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20211203
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2014
DP  - 2014
TI  - Expression and clinical significance of YAP, TAZ, and AREG in hepatocellular 
      carcinoma.
PG  - 261365
LID - 10.1155/2014/261365 [doi]
LID - 261365
AB  - PURPOSE: Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two 
      important effectors of Hippo pathway controlling the balance of organ size and 
      carcinogenesis. Amphiregulin (AREG) is a member of the epidermal growth factor 
      family, a direct target gene of YAP and TAZ. The role of these proteins in 
      hepatocellular carcinoma (HCC) is unclear. METHODS: The expression of YAP, TAZ, 
      and AREG in HCC was analyzed by immunohistochemical staining. The level of 
      secreted serum AREG was also assayed by enzyme-linked immunosorbent (ELISA) 
      assay. RESULTS: YAP, TAZ, and AREG were expressed in 69.2% (27/39), 66.7% 
      (26/39), and 61.5% (24/39) of HCC patients. The expression of YAP was 
      significantly correlated with Edmondson stage (P>0.05), serum AFP level (P>0.05), 
      and HCC prognosis (P>0.05). AREG expression was also significantly correlated 
      with Edmondson stage (P>0.05) and serum AFP level (P>0.05). In addition, the 
      expression of serum AREG was higher than serum AFP in HCC patients. Further 
      multivariate analysis showed that YAP expression was an independent prognostic 
      factor that significantly affected the overall survival of HCC patients. 
      CONCLUSIONS: YAP maybe an independent prognostic indicator for HCC patients and 
      serum AREG may be a serological biomarker of HCC.
FAU - Han, Su-xia
AU  - Han SX
AD  - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Medical College, Xi'an, Shaanxi 710061, China.
FAU - Bai, E
AU  - Bai E
AD  - Center of Maternal and Child Health, The First Affiliated Hospital of Xi'an 
      Jiaotong University Medical College, Xi'an, Shaanxi 710061, China.
FAU - Jin, Gui-hua
AU  - Jin GH
AD  - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Medical College, Xi'an, Shaanxi 710061, China.
FAU - He, Chen-chen
AU  - He CC
AD  - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Medical College, Xi'an, Shaanxi 710061, China.
FAU - Guo, Xi-jing
AU  - Guo XJ
AD  - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Medical College, Xi'an, Shaanxi 710061, China.
FAU - Wang, Li-juan
AU  - Wang LJ
AD  - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Medical College, Xi'an, Shaanxi 710061, China.
FAU - Li, Meng
AU  - Li M
AD  - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Medical College, Xi'an, Shaanxi 710061, China.
FAU - Ying, Xia
AU  - Ying X
AD  - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Medical College, Xi'an, Shaanxi 710061, China.
FAU - Zhu, Qing
AU  - Zhu Q
AD  - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Medical College, Xi'an, Shaanxi 710061, China.
LA  - eng
PT  - Journal Article
DEP - 20140422
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (AFP protein, human)
RN  - 0 (AREG protein, human)
RN  - 0 (Amphiregulin)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (EGF Family of Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (YY1AP1 protein, human)
RN  - 0 (alpha-Fetoproteins)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.1.- (TAFAZZIN protein, human)
SB  - IM
MH  - Acyltransferases
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Amphiregulin
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoma, Hepatocellular/diagnosis/*genetics/mortality/pathology
MH  - Cell Cycle Proteins
MH  - EGF Family of Proteins/*genetics
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Liver Neoplasms/diagnosis/*genetics/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Nuclear Proteins/*genetics
MH  - Prognosis
MH  - Survival Analysis
MH  - Transcription Factors/*genetics
MH  - alpha-Fetoproteins/*genetics
PMC - PMC4016924
EDAT- 2014/05/27 06:00
MHDA- 2014/12/15 06:00
PMCR- 2014/04/22
CRDT- 2014/05/27 06:00
PHST- 2014/01/31 00:00 [received]
PHST- 2014/04/02 00:00 [accepted]
PHST- 2014/05/27 06:00 [entrez]
PHST- 2014/05/27 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2014/04/22 00:00 [pmc-release]
AID - 10.1155/2014/261365 [doi]
PST - ppublish
SO  - J Immunol Res. 2014;2014:261365. doi: 10.1155/2014/261365. Epub 2014 Apr 22.