PMID- 24861232
OWN - NLM
STAT- MEDLINE
DCOM- 20150609
LR  - 20140912
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 28
IP  - 9
DP  - 2014 Sep
TI  - Impact of donor kidney function and donor age on poor outcome of living-unrelated 
      kidney transplantation (KT) in comparison with living-related KT.
PG  - 953-60
LID - 10.1111/ctr.12388 [doi]
AB  - Living-unrelated donors (LURD) have been widely used for kidney transplantation 
      (KT). We retrospectively reviewed 779 patients who underwent living-donor KT from 
      2000 to 2012, to compare outcomes of 264 KT from LURD and 515 from living-related 
      donors (LRD), and to identify risk factors for living KT. Median follow-up was 
      67 months. Mean donor age, total human leukocyte antigen (HLA) mismatches, and 
      HLA-DR mismatches were higher, and mean estimated glomerular filtration rate 
      (eGFR) was lower in LURD. Acute rejection (AR)-free survival (p = 0.018) and 
      graft survival (p = 0.025) were lower for LURD than LRD, whereas patient survival 
      rate was comparable. Cox regression analysis showed HLA-DR mismatches (OR 1.75 
      for one mismatch; OR 2.19 for two mismatches), recipient age </= 42 yr, and donor 
      age > 50 yr were significant risk factors for acute rejection. For graft 
      survival, AR and donor eGFR (OR 1.90, p = 0.035) were significant. We also 
      identified significant impact of recipient age > 50 yr and diabetes for patient 
      survival. However, KT from LURD was not a significant risk factor for AR 
      (p = 0.368), graft survival (p = 0.205), and patient survival (p = 0.836). Our 
      data suggest that donor eGFR and donor age are independent risk factors for 
      clinical outcomes of living KT, which can be related with poor outcome of KT from 
      LURD.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Park, Kyung Sun
AU  - Park KS
AD  - Division of Nephrology, Department of Internal Medicine, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Shin, Jung-Ho
AU  - Shin JH
FAU - Jang, Hye Ryoun
AU  - Jang HR
FAU - Lee, Jung Eun
AU  - Lee JE
FAU - Huh, Woo Seong
AU  - Huh WS
FAU - Kim, Yoon Goo
AU  - Kim YG
FAU - Oh, Ha Young
AU  - Oh HY
FAU - Kim, Dae Joong
AU  - Kim DJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140716
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate/*physiology
MH  - Graft Survival/*physiology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kidney/*physiology
MH  - Kidney Failure, Chronic/physiopathology/*surgery
MH  - Kidney Function Tests
MH  - *Kidney Transplantation
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Rate
OTO - NOTNLM
OT  - HLA-DR mismatches
OT  - Living-unrelated kidney transplantation
OT  - donor estimated glomerular filtration rate
EDAT- 2014/05/28 06:00
MHDA- 2015/06/10 06:00
CRDT- 2014/05/28 06:00
PHST- 2014/05/21 00:00 [accepted]
PHST- 2014/05/28 06:00 [entrez]
PHST- 2014/05/28 06:00 [pubmed]
PHST- 2015/06/10 06:00 [medline]
AID - 10.1111/ctr.12388 [doi]
PST - ppublish
SO  - Clin Transplant. 2014 Sep;28(9):953-60. doi: 10.1111/ctr.12388. Epub 2014 Jul 16.