PMID- 24861575
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 1423-002X (Electronic)
IS  - 0378-7346 (Print)
IS  - 0378-7346 (Linking)
VI  - 78
IP  - 1
DP  - 2014
TI  - Quantitative T2 changes and susceptibility-weighted magnetic resonance imaging in 
      murine pregnancy.
PG  - 33-40
LID - 10.1159/000362552 [doi]
AB  - OBJECTIVE: To evaluate gestational age-dependent changes in the T2 relaxation 
      time in normal murine placentas in vivo. The role of susceptibility-weighted 
      imaging (SWI) in visualization of the murine fetal anatomy was also elucidated. 
      METHODS: Timed-pregnant CD-1 mice at gestational day (GD) 12 and GD17 underwent 
      magnetic resonance imaging. Multi-echo spin echo and SWI data were acquired. The 
      placental T2 values on GD12 and GD17 were quantified. To account for the 
      influence of systemic maternal physiological factors on placental perfusion, 
      maternal muscle was used as a reference for T2 normalization. A linear 
      mixed-effects model was used to fit the normalized T2 values, and the 
      significance of the coefficients was tested. Fetal SWI images were processed and 
      reviewed for venous vasculature and skeletal structures. RESULTS: The average 
      placental T2 value decreased significantly on GD17 (40.17 +/- 4.10 ms) compared to 
      the value on GD12 (55.78 +/- 8.13 ms). The difference in normalized T2 values also 
      remained significant (p = 0.001). Using SWI, major fetal venous structures like 
      the cardinal vein, the subcardinal vein, and the portal vein were visualized on 
      GD12. In addition, fetal skeletal structures could also be discerned on GD17. 
      CONCLUSION: The T2 value of a normal murine placenta decreases with advancing 
      gestation. SWI provided clear visualization of the fetal venous vasculature and 
      bony structures. (c) 2014 S. Karger AG, Basel.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Krishnamurthy, Uday
AU  - Krishnamurthy U
AD  - Department of Radiology, Wayne State University School of Medicine, Detroit, 
      Mich., USA.
FAU - Szalai, Gabor
AU  - Szalai G
FAU - Neelavalli, Jaladhar
AU  - Neelavalli J
FAU - Shen, Yimin
AU  - Shen Y
FAU - Chaiworapongsa, Tinnakorn
AU  - Chaiworapongsa T
FAU - Hernandez-Andrade, Edgar
AU  - Hernandez-Andrade E
FAU - Than, Nandor Gabor
AU  - Than NG
FAU - Xu, Zhonghui
AU  - Xu Z
FAU - Yeo, Lami
AU  - Yeo L
FAU - Haacke, Mark
AU  - Haacke M
FAU - Romero, Roberto
AU  - Romero R
LA  - eng
GR  - HHSN275201300006C/HD/NICHD NIH HHS/United States
GR  - R42 HL112580/HL/NHLBI NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - 1R42HL112580-01A1/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140522
PL  - Switzerland
TA  - Gynecol Obstet Invest
JT  - Gynecologic and obstetric investigation
JID - 7900587
SB  - IM
MH  - Animals
MH  - Female
MH  - Fetus/*anatomy & histology/*blood supply
MH  - *Gestational Age
MH  - *Magnetic Resonance Imaging
MH  - Mice
MH  - Placenta/anatomy & histology/blood supply
MH  - Pregnancy
MH  - Veins/embryology
PMC - PMC4119876
MID - NIHMS598191
EDAT- 2014/05/28 06:00
MHDA- 2015/03/31 06:00
PMCR- 2015/05/22
CRDT- 2014/05/28 06:00
PHST- 2014/01/13 00:00 [received]
PHST- 2014/03/24 00:00 [accepted]
PHST- 2014/05/28 06:00 [entrez]
PHST- 2014/05/28 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2015/05/22 00:00 [pmc-release]
AID - 000362552 [pii]
AID - 10.1159/000362552 [doi]
PST - ppublish
SO  - Gynecol Obstet Invest. 2014;78(1):33-40. doi: 10.1159/000362552. Epub 2014 May 
      22.