PMID- 24862078
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20161125
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 99
DP  - 2014 Oct 1
TI  - Dopamine release in nucleus accumbens during rewarded task switching measured by 
      [(1)(1)C]raclopride.
PG  - 357-64
LID - S1053-8119(14)00412-1 [pii]
LID - 10.1016/j.neuroimage.2014.05.047 [doi]
AB  - Reward and motivation have positive influences on cognitive-control processes in 
      numerous settings. Models of reward implicate corticostriatal loops and the 
      dopamine (DA) system, with special emphasis on D2 receptors in nucleus accumbens 
      (NAcc). In this study, 11 right-handed males (35-40 years) were scanned with 
      positron emission tomography (PET) in a single [(11)C]raclopride dynamic scan 
      during rewarded and non-rewarded task switching. Rewarded task switching 
      (relative to baseline task switching) decreased [(11)C]raclopride binding in 
      NAcc. Decreasing NAcc [(11)C]raclopride binding was strongly associated with task 
      reaction time measures that reflect individual differences in effort and control 
      strategies. Voxelwise analyses additionally revealed reward-related DA release in 
      anterodorsal caudate, a region previously associated with task-switching. These 
      PET findings provide evidence for striatal DA release during motivated cognitive 
      control, and further suggest that NAcc DA release predicts the task reaction time 
      benefits of reward incentives.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Jonasson, Lars S
AU  - Jonasson LS
AD  - Department of Radiation Sciences, Umea University, SE-901 87 Umea, Sweden; Umea 
      Center for Functional Brain Imaging (UFBI), Umea University, SE-901 87 Umea, 
      Sweden; Centre for Population Studies, Ageing and Living Conditions, Umea 
      University, SE-901 87 Umea, Sweden. Electronic address: 
      lars.jonasson@diagrad.umu.se.
FAU - Axelsson, Jan
AU  - Axelsson J
AD  - Department of Radiation Sciences, Umea University, SE-901 87 Umea, Sweden.
FAU - Riklund, Katrine
AU  - Riklund K
AD  - Department of Radiation Sciences, Umea University, SE-901 87 Umea, Sweden; Umea 
      Center for Functional Brain Imaging (UFBI), Umea University, SE-901 87 Umea, 
      Sweden.
FAU - Braver, Todd S
AU  - Braver TS
AD  - Department of Psychology, Washington University, St Louis, MO 63130, USA.
FAU - Ogren, Mattias
AU  - Ogren M
AD  - Department of Radiation Sciences, Umea University, SE-901 87 Umea, Sweden.
FAU - Backman, Lars
AU  - Backman L
AD  - Aging Research Center, Karolinska Institute, SE-113 30 Stockholm, Sweden.
FAU - Nyberg, Lars
AU  - Nyberg L
AD  - Department of Radiation Sciences, Umea University, SE-901 87 Umea, Sweden; Umea 
      Center for Functional Brain Imaging (UFBI), Umea University, SE-901 87 Umea, 
      Sweden; Department of Integrative Medical Biology, Physiology, Umea University, 
      SE-901 87 Umea, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140523
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - 0 (Dopamine Antagonists)
RN  - 430K3SOZ7G (Raclopride)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adult
MH  - Attention/physiology
MH  - Cues
MH  - Dopamine/*metabolism
MH  - *Dopamine Antagonists
MH  - Female
MH  - Humans
MH  - Male
MH  - Nucleus Accumbens/*diagnostic imaging/*metabolism
MH  - Positron-Emission Tomography
MH  - Psychomotor Performance/physiology
MH  - *Raclopride
MH  - Reaction Time/physiology
MH  - *Reward
OTO - NOTNLM
OT  - Dopamine
OT  - Motivation
OT  - Nucleus accumbens
OT  - PET
OT  - Reward
OT  - Working memory
EDAT- 2014/05/28 06:00
MHDA- 2015/04/14 06:00
CRDT- 2014/05/28 06:00
PHST- 2013/11/30 00:00 [received]
PHST- 2014/03/10 00:00 [revised]
PHST- 2014/05/16 00:00 [accepted]
PHST- 2014/05/28 06:00 [entrez]
PHST- 2014/05/28 06:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
AID - S1053-8119(14)00412-1 [pii]
AID - 10.1016/j.neuroimage.2014.05.047 [doi]
PST - ppublish
SO  - Neuroimage. 2014 Oct 1;99:357-64. doi: 10.1016/j.neuroimage.2014.05.047. Epub 
      2014 May 23.