PMID- 24862355 OWN - NLM STAT- MEDLINE DCOM- 20150522 LR - 20140825 IS - 1095-9564 (Electronic) IS - 1074-7427 (Linking) VI - 114 DP - 2014 Oct TI - Recent memory for socially transmitted food preferences in rats does not depend on the hippocampus. PG - 113-6 LID - S1074-7427(14)00089-6 [pii] LID - 10.1016/j.nlm.2014.05.006 [doi] AB - The standard model of systems consolidation holds that the hippocampus (HPC) is involved only in the initial storage and retrieval of a memory. With time hippocampal-neocortical interactions slowly strengthen the neocortical memory, ultimately enabling retrieval of the memory without the HPC. Key support for this idea comes from experiments measuring memory recall in the socially-transmitted food preference (STFP) task in rats. HPC damage within a day or two of STFP learning can abolish recall, but similar damage five or more days after learning has no effect. We hypothesize that disruption of cellular consolidation outside the HPC could contribute to the amnesia with recent memories, perhaps playing a more important role than the loss of HPC. This view predicts that intraHPC infusion of Tetrodotoxin (TTX), which can block conduction of action potentials from the lesion sites, will block the retrograde amnesia in the STFP task. Here we confirm the previously reported retrograde amnesia with neurotoxic HPC damage within the first day after learning, but show that co-administration of TTX with the neurotoxin blocks the retrograde amnesia despite very extensive HPC damage. These results indicate that HPC damage disrupts cellular consolidation of the recent memory elsewhere; STFP memory may not ever depend on the HPC. CI - Copyright (c) 2014 Elsevier Inc. All rights reserved. FAU - Thapa, Rajat AU - Thapa R AD - Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive W, Lethbridge, AB T1K 3M4, Canada. Electronic address: rajat.thapa@uleth.ca. FAU - Sparks, Fraser T AU - Sparks FT AD - Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive W, Lethbridge, AB T1K 3M4, Canada. Electronic address: fs1111@nyu.edu. FAU - Hanif, Wahab AU - Hanif W AD - Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive W, Lethbridge, AB T1K 3M4, Canada. Electronic address: whanif@ualberta.ca. FAU - Gulbrandsen, Tine AU - Gulbrandsen T AD - Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive W, Lethbridge, AB T1K 3M4, Canada. Electronic address: tine.gulbrandsen@uleth.ca. FAU - Sutherland, Robert J AU - Sutherland RJ AD - Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive W, Lethbridge, AB T1K 3M4, Canada. Electronic address: robert.sutherland@uleth.ca. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140523 PL - United States TA - Neurobiol Learn Mem JT - Neurobiology of learning and memory JID - 9508166 RN - 0 (Sodium Channel Blockers) RN - 4368-28-9 (Tetrodotoxin) SB - IM MH - *Animal Communication MH - Animals MH - Food Preferences/*physiology MH - Hippocampus/drug effects/*physiology MH - Learning/drug effects/physiology MH - Male MH - Mental Recall/drug effects/*physiology MH - Rats MH - *Social Behavior MH - Sodium Channel Blockers/pharmacology MH - Tetrodotoxin/pharmacology OTO - NOTNLM OT - Hippocampus OT - Rat OT - Retrograde amnesia OT - Socially transmitted food preference OT - Systems consolidation EDAT- 2014/05/28 06:00 MHDA- 2015/05/23 06:00 CRDT- 2014/05/28 06:00 PHST- 2014/01/31 00:00 [received] PHST- 2014/04/23 00:00 [revised] PHST- 2014/05/16 00:00 [accepted] PHST- 2014/05/28 06:00 [entrez] PHST- 2014/05/28 06:00 [pubmed] PHST- 2015/05/23 06:00 [medline] AID - S1074-7427(14)00089-6 [pii] AID - 10.1016/j.nlm.2014.05.006 [doi] PST - ppublish SO - Neurobiol Learn Mem. 2014 Oct;114:113-6. doi: 10.1016/j.nlm.2014.05.006. Epub 2014 May 23.