PMID- 24862657
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20220330
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 56
DP  - 2014 Sep
TI  - Inflammatory mediators of cognitive impairment in bipolar disorder.
PG  - 18-27
LID - S0022-3956(14)00123-X [pii]
LID - 10.1016/j.jpsychires.2014.04.017 [doi]
AB  - OBJECTIVES: Recent studies have pointed to neuroinflammation, oxidative stress 
      and neurotrophic factors as key mediators in the pathophysiology of mood 
      disorders. Little is however known about the cascade of biological episodes 
      underlying the cognitive deficits observed during the acute and euthymic phases 
      of bipolar disorder (BD). The aim of this review is to assess the potential 
      association between cognitive impairment and biomarkers of inflammation, 
      oxidative stress and neurotrophic activity in BD. METHODS: Scopus (all 
      databases), Pubmed and Ovid Medline were systematically searched with no language 
      or year restrictions, up to November 2013, for human studies that collected both 
      inflammatory markers and cognitive data in BD. Selected search terms were bipolar 
      disorder, depression, mania, psychosis, inflammatory, cognitive and neurotrophic. 
      RESULTS: Ten human studies satisfied the criteria for consideration. The findings 
      showed that high levels of peripheral inflammatory-cytokine, oxidative stress and 
      reduced brain derived neurotrophic factor (BDNF) levels were associated with poor 
      cognitive performance. The BDNF val66met polymorphism is a potential 
      vulnerability factor for cognitive impairment in BD. CONCLUSIONS: Current data 
      provide preliminary evidence of a link between the cognitive decline observed in 
      BD and mechanisms of neuroinflammation and neuroprotection. The identification of 
      BD specific inflammatory markers and polymorphisms in inflammatory response genes 
      may be of assistance for therapeutic intervention.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Bauer, Isabelle E
AU  - Bauer IE
AD  - University of Texas Health Science Center at Houston, Department of Psychiatry 
      and Behavioral Sciences, 77054 Houston, TX, United States. Electronic address: 
      Isabelle.E.Bauer@uth.tmc.edu.
FAU - Pascoe, Michaela C
AU  - Pascoe MC
AD  - Department of Clinical Neuroscience and Rehabilitation, Sahlgrenska Academy at 
      University of Gothenburg, Box 440, 40530 Gothenburg, Sweden.
FAU - Wollenhaupt-Aguiar, Bianca
AU  - Wollenhaupt-Aguiar B
AD  - Laboratorio de Psiquiatria Molecular, Instituto Nacional de Ciencia e Tecnologia 
      - Translacional em Medicina (INCT), Hospital de Clinicas de Porto Alegre, 
      Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Universidade 
      Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
FAU - Kapczinski, Flavio
AU  - Kapczinski F
AD  - University of Texas Health Science Center at Houston, Department of Psychiatry 
      and Behavioral Sciences, 77054 Houston, TX, United States; Laboratorio de 
      Psiquiatria Molecular, Instituto Nacional de Ciencia e Tecnologia - Translacional 
      em Medicina (INCT), Hospital de Clinicas de Porto Alegre, Universidade Federal do 
      Rio Grande do Sul, Porto Alegre, RS, Brazil.
FAU - Soares, Jair C
AU  - Soares JC
AD  - University of Texas Health Science Center at Houston, Department of Psychiatry 
      and Behavioral Sciences, 77054 Houston, TX, United States.
LA  - eng
GR  - R01 MH085667/MH/NIMH NIH HHS/United States
GR  - UL1 TR000371/TR/NCATS NIH HHS/United States
GR  - 1R01MH085667/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20140502
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - Bipolar Disorder/*complications/genetics/*immunology
MH  - Cognition Disorders/*complications/genetics/*immunology
MH  - Humans
MH  - Neuroimmunomodulation/genetics/physiology
PMC - PMC4167370
MID - NIHMS601042
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Cognitive functioning
OT  - Neuroinflammation
OT  - Neurotrophin
OT  - Oxidative stress
COIS- Declaration of interest Dr Bauer, Dr Pascoe and Dr Wollenhaupt-Aguiar have no 
      conflicts of interest Professor Kapczinski has received grants/research support 
      from Astra-Zeneca, Eli Lilly, Janssen-Cilag, Servier, CNPq, CAPES, NARSAD and 
      Stanley Medical Research Institute; has been a member of the board of speakers 
      for Astra-Zeneca, Eli Lilly, Janssen and Servier; and has served as a consultant 
      for Servier. Professor J. C. Soares has received grants/research support from 
      Forrest, BMS, Merck, Stanley Medical Research Institute, NIH and has been a 
      speaker for Pfizer and Abbott.
EDAT- 2014/05/28 06:00
MHDA- 2015/02/20 06:00
PMCR- 2015/09/01
CRDT- 2014/05/28 06:00
PHST- 2013/11/19 00:00 [received]
PHST- 2014/04/17 00:00 [revised]
PHST- 2014/04/21 00:00 [accepted]
PHST- 2014/05/28 06:00 [entrez]
PHST- 2014/05/28 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - S0022-3956(14)00123-X [pii]
AID - 10.1016/j.jpsychires.2014.04.017 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2014 Sep;56:18-27. doi: 10.1016/j.jpsychires.2014.04.017. Epub 
      2014 May 2.