PMID- 24863351
OWN - NLM
STAT- MEDLINE
DCOM- 20150102
LR  - 20171116
IS  - 1875-5364 (Electronic)
IS  - 1875-5364 (Linking)
VI  - 12
IP  - 4
DP  - 2014 Apr
TI  - Alkaloids of Nitraria sibirica Pall. decrease hypertension and albuminuria in 
      angiotensin II-salt hypertension.
PG  - 266-72
LID - S1875-5364(14)60053-4 [pii]
LID - 10.1016/S1875-5364(14)60053-4 [doi]
AB  - In traditional Chinese medicine, Nitraria sibirica Pall. (Nitrariaceae) is used 
      to treat hypertension. This study determined the effects of the total alkaloids 
      of the leaves of Nitraria sibirica (NSTA) on blood pressure and albuminuria in 
      mice treated with angiotensin II and a high-salt diet (ANG/HS). Adult mice were 
      divided into three groups: control; infused with angiotensin II and fed a diet 
      containing 4% NaCl (ANG/HS; and ANG/HS plus injection of NSTA (1 mg.kg(-1).d(-1), 
      i.p.). After treatment of these regimens, daily water and food intake, kidney 
      weight, blood pressure, urinary albumin excretion, renal concentrations of 
      inflammatory markers, including soluble intercellular adhesion molecule-1 
      (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1), and the expression of 
      renal fibrosis markers were determined. Compared to the control group, the ANG/HS 
      group had higher blood pressure and urinary albumin excretion. Treatment with 
      NSTA in ANG/HS mice for three weeks significantly reduced blood pressure and 
      urinary albumin excretion. ANG/HS treatment caused elevated levels of sICAM-1 and 
      MCP-1, as well as increased fibrosis markers. Concurrent treatment with ANG/HS 
      and NSTA attenuated the levels and expression of renal inflammatory and fibrosis 
      markers. Treatment with NSTA effectively reduces hypertension-induced albuminuria 
      through the reduction of renal inflammatory and fibrosis markers.
CI  - Copyright (c) 2014 China Pharmaceutical University. Published by Elsevier B.V. All 
      rights reserved.
FAU - Bakri, Mahinur
AU  - Bakri M
AD  - The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 
      830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants 
      Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, 
      Chinese Academy of Sciences, Urumqi 830011, China.
FAU - Yi, Yang
AU  - Yi Y
AD  - The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 
      830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants 
      Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, 
      Chinese Academy of Sciences, Urumqi 830011, China.
FAU - Chen, Ling-Dan
AU  - Chen LD
AD  - Department of Physiology, Georgia Regents University, Augusta, GA 30912, USA.
FAU - Aisa, Haji Akber
AU  - Aisa HA
AD  - The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 
      830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants 
      Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, 
      Chinese Academy of Sciences, Urumqi 830011, China.
FAU - Wang, Mong-Heng
AU  - Wang MH
AD  - Department of Physiology, Georgia Regents University, Augusta, GA 30912, USA. 
      Electronic address: mwang@gru.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin J Nat Med
JT  - Chinese journal of natural medicines
JID - 101504416
RN  - 0 (Alkaloids)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Sodium Chloride, Dietary)
RN  - 11128-99-7 (Angiotensin II)
SB  - IM
MH  - Albuminuria/*drug therapy/metabolism/physiopathology
MH  - Alkaloids/*administration & dosage
MH  - Angiotensin II/*metabolism
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Chemokine CCL2/metabolism
MH  - Drugs, Chinese Herbal/*administration & dosage
MH  - Humans
MH  - Hypertension/*drug therapy/metabolism/physiopathology
MH  - Magnoliopsida/*chemistry
MH  - Male
MH  - Mice
MH  - Rats, Sprague-Dawley
MH  - Sodium Chloride, Dietary/adverse effects/metabolism
OTO - NOTNLM
OT  - Albuminuria
OT  - Alkaloids
OT  - Blood pressure
OT  - High salt diet
OT  - Hypertension
OT  - Nitraria sibirica
EDAT- 2014/05/28 06:00
MHDA- 2015/01/03 06:00
CRDT- 2014/05/28 06:00
PHST- 2012/11/23 00:00 [received]
PHST- 2014/05/28 06:00 [entrez]
PHST- 2014/05/28 06:00 [pubmed]
PHST- 2015/01/03 06:00 [medline]
AID - S1875-5364(14)60053-4 [pii]
AID - 10.1016/S1875-5364(14)60053-4 [doi]
PST - ppublish
SO  - Chin J Nat Med. 2014 Apr;12(4):266-72. doi: 10.1016/S1875-5364(14)60053-4.