PMID- 24863462
OWN - NLM
STAT- MEDLINE
DCOM- 20141015
LR  - 20140825
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 121
IP  - 9
DP  - 2014 Sep
TI  - Vitreoretinal interface changes in geographic atrophy.
PG  - 1734-9
LID - S0161-6420(14)00310-8 [pii]
LID - 10.1016/j.ophtha.2014.03.036 [doi]
AB  - PURPOSE: Geographic atrophy (GA) is the end-stage manifestation of atrophic 
      age-related macular degeneration (AMD). The disease progresses slowly over time, 
      eventually causing loss of central vision. Its cause and pathomechanism are not 
      fully known. Previous studies have suggested that vitreoretinal traction (VRT) 
      may contribute to the progression of neovascular AMD. The aim of this study was 
      to examine whether an association between changes at the vitreoretinal interface 
      (VRI), in particular traction (VRT), and the characteristics and progression of 
      GA in eyes with dry AMD can be established. DESIGN: Clinic-based prospective 
      cohort study. PARTICIPANTS: A total of 97 patients (age range, 61-90 years; mean, 
      78.4 years) with GA secondary to dry AMD were enrolled. Patients exhibiting 
      neovascular signs on fluorescein angiography in either eye were excluded. 
      METHODS: The VRI changes were examined using spectral-domain optical coherence 
      tomography (SD-OCT). Characteristics of GA were examined using fundus 
      autofluorescence (FAF) imaging. All imaging was performed using a Spectralis 
      SLO+OCT device (Heidelberg Engineering, Heidelberg, Germany); GA area was 
      measured using the Region Finder (Heidelberg Engineering) software native to the 
      Spectralis platform. MAIN OUTCOME MEASURES: Area and increase in area of GA. 
      RESULTS: A total of 97 eyes were examined. Vitreoretinal traction was found in 39 
      eyes (40%). The GA area at baseline was 6.65+/-5.64 mm(2) in eyes with VRT and 
      5.73+/-4.72 mm(2) in eyes with no VRT. The annual rate of progression of GA area 
      progression was 2.99+/-0.66 mm(2) in eyes with VRT and 1.45+/-0.67mm(2) in eyes 
      without VRT. Differences between groups in both parameters were statistically 
      significant (n = 97 total number of eyes; P<0.001). Multiple regression analysis 
      confirmed this finding (B = 0.714, P<0.001; F3,93 = 72.542, P<0.001; adjusted 
      R(2) = 0.691) CONCLUSIONS: Our results indicate an association between VRT and an 
      increased rate of progression of GA area in dry AMD. Monitoring VRT may 
      contribute to an improved estimate of the prospective time of visual loss and to 
      a better timing of emerging therapies in dry AMD.
CI  - Copyright (c) 2014 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Abdillahi, Hannan
AU  - Abdillahi H
AD  - Bern Photographic Reading Center, Department of Ophthalmology, University 
      Hospital, Inselspital and University of Bern, Bern, Switzerland.
FAU - Enzmann, Volker
AU  - Enzmann V
AD  - Department of Ophthalmology, University Hospital, Inselspital and University of 
      Bern, Bern, Switzerland.
FAU - Wittwer, Valery V
AU  - Wittwer VV
AD  - Department of Ophthalmology, University Hospital, Inselspital and University of 
      Bern, Bern, Switzerland.
FAU - Wolf, Sebastian
AU  - Wolf S
AD  - Bern Photographic Reading Center, Department of Ophthalmology, University 
      Hospital, Inselspital and University of Bern, Bern, Switzerland; Department of 
      Ophthalmology, University Hospital, Inselspital and University of Bern, Bern, 
      Switzerland.
FAU - Wolf-Schnurrbusch, Ute E K
AU  - Wolf-Schnurrbusch UE
AD  - Bern Photographic Reading Center, Department of Ophthalmology, University 
      Hospital, Inselspital and University of Bern, Bern, Switzerland; Department of 
      Ophthalmology, University Hospital, Inselspital and University of Bern, Bern, 
      Switzerland. Electronic address: ute.wolf@insel.ch.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140523
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease Progression
MH  - Dry Eye Syndromes/*complications
MH  - Female
MH  - Geographic Atrophy/etiology/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
EDAT- 2014/05/28 06:00
MHDA- 2014/10/16 06:00
CRDT- 2014/05/28 06:00
PHST- 2013/08/14 00:00 [received]
PHST- 2014/03/25 00:00 [revised]
PHST- 2014/03/28 00:00 [accepted]
PHST- 2014/05/28 06:00 [entrez]
PHST- 2014/05/28 06:00 [pubmed]
PHST- 2014/10/16 06:00 [medline]
AID - S0161-6420(14)00310-8 [pii]
AID - 10.1016/j.ophtha.2014.03.036 [doi]
PST - ppublish
SO  - Ophthalmology. 2014 Sep;121(9):1734-9. doi: 10.1016/j.ophtha.2014.03.036. Epub 
      2014 May 23.