PMID- 24864507
OWN - NLM
STAT- MEDLINE
DCOM- 20141121
LR  - 20140528
IS  - 0042-465X (Print)
IS  - 0042-465X (Linking)
VI  - 130
IP  - 2
DP  - 2014 Mar-Apr
TI  - [Pathogenesis of retinal vein occlusions].
PG  - 88-92
AB  - Retinal vein occlusion (RVO) is a multifactorial disease and its pathogenesis is 
      still not fully understood. Mechanical, hemodynamic, rheological, coagulation, 
      biochemical, and immunological factors are involved. Two currently prevalent 
      theories of RVO pathogenesis are the mechanical theory and the "coagulopathic" 
      theory. The latter implies an imbalance between thrombogenic factors and 
      antithrombogenic protection. According to some authors, endothelial dysfunction 
      plays a large part in thrombosis development, neoangiogenesis, vascular 
      remodeling, intravascular activation of platelets and leucocytes. In recent 
      studies increasing emphasis is being placed on investigation of immune-mediated 
      mechanisms of vein occlusions. RVO can also be associated with combined hypoxic 
      and free radical tissue damage.
FAU - Mikhailova, M A
AU  - Mikhailova MA
FAU - Sizova, M V
AU  - Sizova MV
FAU - Shelankova, A V
AU  - Shelankova AV
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Russia (Federation)
TA  - Vestn Oftalmol
JT  - Vestnik oftalmologii
JID - 0415216
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Retinal Vein Occlusion/immunology/*physiopathology
EDAT- 2014/05/29 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/05/29 06:00
PHST- 2014/05/29 06:00 [entrez]
PHST- 2014/05/29 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PST - ppublish
SO  - Vestn Oftalmol. 2014 Mar-Apr;130(2):88-92.