PMID- 24865115
OWN - NLM
STAT- MEDLINE
DCOM- 20150121
LR  - 20211203
IS  - 1478-6427 (Electronic)
IS  - 1478-6419 (Linking)
VI  - 28
IP  - 22
DP  - 2014
TI  - Effects of olive leaf polyphenols on male mouse brain NGF, BDNF and their 
      receptors TrkA, TrkB and p75.
PG  - 1970-84
LID - 10.1080/14786419.2014.918977 [doi]
AB  - In this study, we evaluated, in the mouse, the effects of 20 mg/kg i.p. daily 
      administration for 15 consecutive days of a blend of polyphenols, containing 
      mostly oleuropein, extracted from the olive leaves (Olea europaea) on brain nerve 
      growth factor (NGF) and brain-derived neurotrophic factor (BDNF) and on the 
      expression of their receptors, TrkA, TrkB and p75. Polyphenols decreased the 
      levels of reduced glutathione (GSH) and increased the levels of NGF and BDNF in 
      the serum. In the brain, we found decreased levels of NGF and BDNF in the 
      hippocampus and striatum but elevated levels of NGF in the olfactory lobes and 
      hypothalamus and again BDNF potentiation in the olfactory lobes. No changes in 
      TrkA, TrkB and p75 expression were observed. In conclusion, olive polyphenols may 
      not only elicit an activation of the rodent olfactory system by increasing the 
      levels of NGF and BDNF but also be stressing for the animal by reducing both the 
      levels of hippocampal NGF/BDNF and serum GSH and increasing serum levels of NGF 
      and BDNF.
FAU - Carito, Valentina
AU  - Carito V
AD  - a Institute of Cellular Biology and Neurobiology, National Research Council (CNR) 
      , via del Fosso di Fiorano 64, 00143 Rome , Italy.
FAU - Venditti, Alessandro
AU  - Venditti A
FAU - Bianco, Armandodoriano
AU  - Bianco A
FAU - Ceccanti, Mauro
AU  - Ceccanti M
FAU - Serrilli, Anna Maria
AU  - Serrilli AM
FAU - Chaldakov, George
AU  - Chaldakov G
FAU - Tarani, Luigi
AU  - Tarani L
FAU - De Nicolo, Sara
AU  - De Nicolo S
FAU - Fiore, Marco
AU  - Fiore M
LA  - eng
PT  - Journal Article
DEP - 20140527
PL  - England
TA  - Nat Prod Res
JT  - Natural product research
JID - 101167924
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Iridoid Glucosides)
RN  - 0 (Iridoids)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Polyphenols)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 2O4553545L (oleuropein)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/*drug effects
MH  - Glutathione/analysis/blood/drug effects
MH  - Iridoid Glucosides
MH  - Iridoids/administration & dosage/pharmacology
MH  - Male
MH  - Mice
MH  - Models, Animal
MH  - Nerve Growth Factor/drug effects
MH  - Nerve Growth Factors/pharmacology
MH  - Neurons/drug effects
MH  - Olea/*chemistry
MH  - Plant Leaves/chemistry
MH  - Polyphenols/administration & dosage/*pharmacology
MH  - Receptor, trkA/*drug effects
MH  - Receptor, trkB/*drug effects
MH  - Receptors, Nerve Growth Factor/*drug effects
OTO - NOTNLM
OT  - BDNF
OT  - NGF
OT  - olive
OT  - polyphenols
EDAT- 2014/05/29 06:00
MHDA- 2015/01/22 06:00
CRDT- 2014/05/29 06:00
PHST- 2014/05/29 06:00 [entrez]
PHST- 2014/05/29 06:00 [pubmed]
PHST- 2015/01/22 06:00 [medline]
AID - 10.1080/14786419.2014.918977 [doi]
PST - ppublish
SO  - Nat Prod Res. 2014;28(22):1970-84. doi: 10.1080/14786419.2014.918977. Epub 2014 
      May 27.