PMID- 24865143
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20240321
IS  - 1873-5894 (Electronic)
IS  - 0730-725X (Print)
IS  - 0730-725X (Linking)
VI  - 32
IP  - 7
DP  - 2014 Sep
TI  - Evaluation of aortic stenosis severity using 4D flow jet shear layer detection 
      for the measurement of valve effective orifice area.
PG  - 891-8
LID - S0730-725X(14)00142-8 [pii]
LID - 10.1016/j.mri.2014.04.017 [doi]
AB  - AIMS: The objective of this study was to evaluate the potential of 4D flow MRI to 
      assess valve effective orifice area (EOA) in patients with aortic stenosis as 
      determined by the jet shear layer detection (JSLD) method. METHODS AND RESULTS: 
      An in-vitro stenosis phantom was used for validation and in-vivo imaging was 
      performed in 10 healthy controls and 40 patients with aortic stenosis. EOA was 
      calculated by the JSLD method using standard 2D phase contrast MRI (PC-MRI) and 
      4D flow MRI measurements (EOAJSLD-2D and EOAJSLD-4D, respectively). As a 
      reference standard, the continuity equation was used to calculate EOA (EOACE) 
      with the 2D PC-MRI velocity field and compared to the EOAJSLD measurements. The 
      in-vitro results exhibited excellent agreement between flow theory 
      (EOA=0.78cm(2)) and experimental measurement (EOAJSLD-4D=0.78+/-0.01cm(2)) for peak 
      velocities ranging from 0.9 to 3.7m/s. In-vivo results showed good correlation 
      and agreement between EOAJSLD-2D and EOACE (r=0.91, p<0.001; bias: 
      -0.01+/-0.38cm(2); agreement limits: 0.75 to -0.77cm(2)), and between EOAJSLD-4D 
      and EOACE (r=0.95, p<0.001; bias: -0.09+/-0.26cm(2); limits: 0.43 to -0.62cm(2)). 
      CONCLUSION: This study demonstrates the feasibility of measuring EOAJSLD using 4D 
      flow MRI. The technique allows for optimization of the EOA measurement position 
      by visualizing the 3D vena contracta, and avoids potential sources of EOACE 
      measurement variability.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Garcia, Julio
AU  - Garcia J
AD  - Radiology, Northwestern University, Chicago, USA; Medicine, Laval University, 
      Quebec, Canada. Electronic address: julio.flores@northwestern.edu.
FAU - Markl, Michael
AU  - Markl M
AD  - Radiology, Northwestern University, Chicago, USA; Biomedical Engineering, 
      Northwestern University, Chicago, USA.
FAU - Schnell, Susanne
AU  - Schnell S
AD  - Radiology, Northwestern University, Chicago, USA.
FAU - Allen, Bradley
AU  - Allen B
AD  - Radiology, Northwestern University, Chicago, USA.
FAU - Entezari, Pegah
AU  - Entezari P
AD  - Radiology, Northwestern University, Chicago, USA.
FAU - Mahadevia, Riti
AU  - Mahadevia R
AD  - Radiology, Northwestern University, Chicago, USA.
FAU - Chris Malaisrie, S
AU  - Chris Malaisrie S
AD  - Division of Cardiothoracic Surgery, Northwestern University, Chicago, USA.
FAU - Pibarot, Philippe
AU  - Pibarot P
AD  - Medicine, Laval University, Quebec, Canada.
FAU - Carr, James
AU  - Carr J
AD  - Radiology, Northwestern University, Chicago, USA.
FAU - Barker, Alex J
AU  - Barker AJ
AD  - Radiology, Northwestern University, Chicago, USA.
LA  - eng
GR  - R01 HL115828/HL/NHLBI NIH HHS/United States
GR  - CAPMC/CIHR/Canada
GR  - R01HL115828/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20140424
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aortic Valve/*pathology
MH  - Aortic Valve Stenosis/*pathology
MH  - Cardiac-Gated Imaging Techniques/methods
MH  - Contrast Media
MH  - Feasibility Studies
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Imaging, Three-Dimensional/*methods
MH  - Magnetic Resonance Angiography/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Phantoms, Imaging
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Severity of Illness Index
PMC - PMC4099275
MID - NIHMS588844
OTO - NOTNLM
OT  - 4D flow MRI
OT  - Aortic stenosis
OT  - Effective orifice area
OT  - Jet shear layer
EDAT- 2014/05/29 06:00
MHDA- 2015/03/31 06:00
PMCR- 2015/09/01
CRDT- 2014/05/29 06:00
PHST- 2013/10/25 00:00 [received]
PHST- 2014/04/16 00:00 [revised]
PHST- 2014/04/17 00:00 [accepted]
PHST- 2014/05/29 06:00 [entrez]
PHST- 2014/05/29 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - S0730-725X(14)00142-8 [pii]
AID - 10.1016/j.mri.2014.04.017 [doi]
PST - ppublish
SO  - Magn Reson Imaging. 2014 Sep;32(7):891-8. doi: 10.1016/j.mri.2014.04.017. Epub 
      2014 Apr 24.