PMID- 24865152
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20220409
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 54
DP  - 2014 Oct 3
TI  - Estrogenic mediation of serotonergic and neurotrophic systems: implications for 
      female mood disorders.
PG  - 13-25
LID - S0278-5846(14)00100-6 [pii]
LID - 10.1016/j.pnpbp.2014.05.009 [doi]
AB  - Clinical research has demonstrated a significant sex difference in the occurrence 
      of depressive disorders. Beginning at pubertal onset, women report a higher 
      incidence of depression than men. Women are also vulnerable to the development of 
      depressive disorders such as premenstrual dysphoric disorder, postpartum 
      depression, and perimenopausal depression. These disorders are associated with 
      reproductive stages involving changes in gonadal hormone levels. Specifically, 
      female depression and female affective behaviors are influenced by estradiol 
      levels. This review argues two major mechanisms by which estrogens influence 
      depression and depressive-like behavior: through interactions with neurotrophic 
      factors and through an influence on the serotonergic system. In particular, 
      estradiol increases brain derived neurotrophic factor (BDNF) levels within the 
      brain, and alters serotonergic expression in a receptor subtype-specific manner. 
      We will take a regional approach, examining these effects of estrogens in the 
      major brain areas implicated in depression. Finally, we will discuss the gaps in 
      our current knowledge of the effects of estrogens on female depression, and the 
      potential utility for estrogen receptor modulators in treatment for this 
      disorder.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Borrow, Amanda P
AU  - Borrow AP
AD  - Psychology Department, Binghamton University, United States.
FAU - Cameron, Nicole M
AU  - Cameron NM
AD  - Psychology Department, Binghamton University, United States. Electronic address: 
      ncameron@binghamton.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140524
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Estrogens)
RN  - 0 (Nerve Growth Factors)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Animals
MH  - Brain/pathology/*physiopathology
MH  - Estrogens/*metabolism
MH  - Female
MH  - Humans
MH  - Mood Disorders/pathology/*physiopathology
MH  - Nerve Growth Factors/*metabolism
MH  - Serotonin/*metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Brain
OT  - Depression
OT  - Estrogen
OT  - Female
OT  - Menstrual
OT  - Perimenopause
OT  - Postpartum
OT  - Serotonin
OT  - Women
EDAT- 2014/05/29 06:00
MHDA- 2015/05/13 06:00
CRDT- 2014/05/29 06:00
PHST- 2014/01/29 00:00 [received]
PHST- 2014/05/13 00:00 [revised]
PHST- 2014/05/14 00:00 [accepted]
PHST- 2014/05/29 06:00 [entrez]
PHST- 2014/05/29 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
AID - S0278-5846(14)00100-6 [pii]
AID - 10.1016/j.pnpbp.2014.05.009 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:13-25. doi: 
      10.1016/j.pnpbp.2014.05.009. Epub 2014 May 24.