PMID- 24867662
OWN - NLM
STAT- MEDLINE
DCOM- 20151028
LR  - 20221207
IS  - 1463-1326 (Electronic)
IS  - 1462-8902 (Linking)
VI  - 17
IP  - 2
DP  - 2015 Feb
TI  - Dipeptidyl peptidase-4 inhibitors can minimize the hypoglycaemic burden and 
      enhance safety in elderly people with diabetes.
PG  - 107-15
LID - 10.1111/dom.12319 [doi]
AB  - The prevalence of type 2 diabetes mellitus (T2DM) among elderly people is 
      increasing. Often associated with disabilities/comorbidities, T2DM lowers the 
      chances of successful aging and is independently associated with frailty and an 
      increased risk of hypoglycaemia, which can be further exacerbated by 
      antihyperglycaemic treatment. From this perspective, the clinical management of 
      T2DM in the elderly is challenging and requires individualization of optimum 
      glycaemic targets depending on comorbidities, cognitive functioning and ability 
      to recognize and self-manage the disease. The lack of solid evidence-based 
      medicine supporting treatment guidelines for older people with diabetes further 
      complicates the matter. Several classes of medicine for the treatment of T2DM are 
      currently available and different drug combinations are often required to achieve 
      individualized glycaemic goals. Many of these drugs, however, carry disadvantages 
      such as the propensity to cause weight gain or hypoglycaemia. Dipeptidyl 
      peptidase-4 (DPP-4) inhibitors, a recent addition to the pharmacological 
      armamentarium, have become widely accepted in clinical practice because of their 
      efficacy, low risk of hypoglycaemia, neutral effect on body weight, and 
      apparently greater safety in patients with kidney failure. Although more 
      information is needed to reach definitive conclusions, growing evidence suggests 
      that DPP-4 inhibitors may become a valuable component in the pharmacological 
      management of elderly people with T2DM. The present review aims to delineate the 
      potential advantages of this pharmacological approach in the treatment of elderly 
      people with T2DM.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Avogaro, A
AU  - Avogaro A
AD  - Department of Medicine, Section of Diabetes and Metabolic Diseases, University of 
      Padova, Padua, Italy.
FAU - Dardano, A
AU  - Dardano A
FAU - de Kreutzenberg, S V
AU  - de Kreutzenberg SV
FAU - Del Prato, S
AU  - Del Prato S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140625
PL  - England
TA  - Diabetes Obes Metab
JT  - Diabetes, obesity & metabolism
JID - 100883645
RN  - 0 (Blood Glucose)
RN  - 0 (Dipeptidyl-Peptidase IV Inhibitors)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Nitriles)
RN  - 0 (Pyrrolidines)
RN  - 0 (hemoglobin A1c protein, human)
RN  - I6B4B2U96P (Vildagliptin)
RN  - PJY633525U (Adamantane)
SB  - IM
MH  - Adamantane/*analogs & derivatives/therapeutic use
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/*drug effects
MH  - Body Weight/drug effects
MH  - Cardiovascular Diseases/blood/etiology/*prevention & control
MH  - Diabetes Mellitus, Type 2/blood/complications/*drug therapy
MH  - Diabetic Angiopathies/blood/*prevention & control
MH  - Dipeptidyl-Peptidase IV Inhibitors/*therapeutic use
MH  - Evidence-Based Medicine
MH  - Glycated Hemoglobin/drug effects
MH  - Humans
MH  - Hypoglycemia/chemically induced/*prevention & control
MH  - Nitriles/*therapeutic use
MH  - Practice Guidelines as Topic
MH  - Pyrrolidines/*therapeutic use
MH  - Quality of Life
MH  - Vildagliptin
OTO - NOTNLM
OT  - comorbidities
OT  - diabetes treatment
OT  - frailty
OT  - hypoglycaemia
OT  - incretin therapy
OT  - renal impairment
EDAT- 2014/05/29 06:00
MHDA- 2015/10/29 06:00
CRDT- 2014/05/29 06:00
PHST- 2013/12/20 00:00 [received]
PHST- 2014/05/19 00:00 [revised]
PHST- 2014/05/20 00:00 [accepted]
PHST- 2014/05/29 06:00 [entrez]
PHST- 2014/05/29 06:00 [pubmed]
PHST- 2015/10/29 06:00 [medline]
AID - 10.1111/dom.12319 [doi]
PST - ppublish
SO  - Diabetes Obes Metab. 2015 Feb;17(2):107-15. doi: 10.1111/dom.12319. Epub 2014 Jun 
      25.